Three stable and simple synthetic routes of labeled D -Mabuterol, D -Bambuterol, and D -Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to H NMR and liquid chromatography-tandem mass spectrometry.

Based on the thiol-ene radical addition reaction, the branched hydroxyl functionalized modified styrene-butadiene-styrene triblock copolymer (SBS-g-OH) was prepared. According to chemical structure characterization, the order of reactivity proved that 1,2-vinyls had a priority to react with 2-mercaptoethanol (MCH) at a low functionalization degree of SBS-g-OH. A novel reaction kinetics model was set up to describe the addition reaction between MCH and 1,2-vinyls; then the effect of reaction time, temperature, and initial concentration ratio of MCH to 1,2-vinyls on functionalization degree of SBS-g-OH were investigated. Subsequently the performances of modified asphalt were investigated, where the softening point, ductility, and needle penetration of SBS-g-OH modified asphalt were almost equal to that of SBS modified asphalt, while the dispersibility of polymer in asphalt and storage stability of modified asphalt had been improved obviously using SBS-g-OH with an appropriate functionalization degree.

This report presents an efficient synthesis of D -clenproperol and D -cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor. Their structures and the isotope-abundance were confirmed by proton nuclear magnetic resonance and liquid chromatography-mass spectrometry.

Two efficient synthetic routes of stable deuterium labelled 2-isopropylthioxanthone were presented with 98.1% and 98.8% isotopic abundance in acceptable yields and excellent chemical purities. Their structures and the isotope-abundance were confirmed according to proton nuclear magnetic resonance and liquid chromatography-mass spectrometry.

aThis report presents an efficient synthesis of [D 6 ]leucocrystal violet. Esterification of p-toluenesulphonyl chloride with [D 4 ]methanol provided [D 3 ]methyl p-toluenesulphonate, which was used to methylate aniline to give [D 6 ]N,Ndimethylaniline. Condensation of [D 6 ]N,N-dimethylaniline with bis[4-(dimethylamino)phenyl]methanol afforded [D 6 ]leucocrystal violet in an overall yield of 30% in three steps.