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Recently, nanoparticle‐triggered in situ catalytic Fenton/Fenton‐like reaction is widely explored for tumor‐specific chemodynamic therapy (CDT). However, despite the great potential of CDT in tumor treatment, insensitive response to the relatively high pH of the tumor sites and the insufficient intratumoral H2O2 level leads to limited efficiency of most Fenton/Fenton‐like reactions, which greatly imped its clinical conversion. This paper reports the fabrication of Fenton‐type bimetallic peroxides for ultrasensitive chemodynamic therapy with high pH‐activated, synergistic effect/H2O2 self‐supply‐mediated cascade Fenton chemistry for the first time. The observations reveal that these bimetallic peroxides exhibit an ultrasensitive acid‐activated decomposition‐mediated Fenton‐like reaction at the relatively high pH of 6.5–7.0, accompanied with highly increased •OH generation efficiency (especially, 40–60‐fold increase at pH 7.0) by the metal‐mediated synergistic effect‐enhanced Fenton chemistry as well as in situ self‐generated H2O2 supplement. Moreover, the bimetallic peroxides exhibit high tumor accumulation which along with a high‐efficiency tumor catalytic‐therapeutic with negligible side effects in vivo. Developing these novel bimetallic peroxides, together with the already demonstrated capacity of the key metals (Fe, Mn, Cu, etc.) for magnetic resonance imaging or photodynamic/immune‐enhanced therapy, will propel interest in development of smart high‐efficiency nanoplatform for cancer theranostics.

We present a simple and efficient method for preconcentrating per- and polyfluorinated alkyl substances (PFAS) in water. Our method was inspired by the sea-spray aerosol enrichment in nature. Gas bubbles in the ocean serve to scavenge surface active material, carrying it to the air-ocean interface, where the bubbles burst and form a sea-spray aerosol. These aerosol particles are enriched in surface-active organic compounds such as free fatty acids and anionic surfactants. In our method, we in situ generate H2 microbubbles by electrochemical water reduction using a porous Ni foam electrode. These H2 bubbles pick up PFAS as they rise through the water column that contains low concentration PFAS. When these bubbles reach the water surface, they burst and produce aerosol droplets that are enriched in PFAS. Using this method, we demonstrated ∼1000-fold preconcentration for ten common PFAS in the concentration range from 1 pM to 1 nM (or ∼0.5 ng/L to 500 ng/L) in 10 min. We also developed a diffusion-limited adsorption model that is in quantitative agreement with the experimental data. In addition, we demonstrated using this method to preconcentrate PFAS in tap water, indicating its potential use for quantitative analysis of PFAS in real-world water samples.