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In this study, the effects of 2-O-β-D-glucopyranosyl-L-ascorbic acid (AA-2βG), a natural ascorbic acid derivative from the fruits of Lycium barbarum, on treating the dextran sulfate sodium (DSS)-induced colitis in mice were investigated. The results revealed that AA-2βG had palliating effects on DSS-induced inflammatory bowel disease (IBD) in terms of slowing down the trends of body weight and solid fecal mass loss, reducing colitis disease activity index, improving serum physiological and biochemical indicators, increasing colon length, blocking proinflammatory cytokines, and increasing tight junction proteins. Additionally, AA-2βG treatment could promote the production of short-chain fatty acids and modulate the composition of the gut microbiota. The key bacteria related to IBD were found to be Porphyromonadaceae, Prevotellaceae, Rikenellaceae, Parasutterella, Parabacteroides, and Clostridium. The results indicated that AA-2βG might treat IBD through the regulation of gut microbiota, suggesting that AA-2βG has the potential to be used as a dietary supplement in the treatment of IBD.

We report on the hydrothermal synthesis of borondoped carbon dots (B-CDs) starting from glucose and boric acid. Doping of the CDs with boron was confirmed by Fourier transform infrared and X-ray photoelectron spectroscopy. The B-CDs have an average diameter of about 4 nm and display blue fluorescence which is dynamically quenched by Fe(III) ions. This finding was exploited to design a method for the determination of Fe(III) in water. The relative fluorescence intensity at 359 nm in the presence and of absence ions is inversely proportional to the concentration of Fe(III) ions, and a Stern-Volmer calibration plot is linear in the concentration range of 0-16 μM, with a 242 nM detection limit. The assay is sensitive, robust and selective.

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