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Chronic obstructive pulmonary disease (COPD) is an intractable disease involving as tickym ucus layer and nanoagents with mucus-penetrating capability offer anew way to deliver drugs.H owever,d rug release from nanovehicles requires optimization to enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined with PEGylated chitosan nanospheres containing the antibiotic amikacin (termed PEG@CS/BPQDs-AM NPs). As ad rug-delivery system, the hydrophilicity of PEG and positive charge of CS facilitate the penetration of nanovehicles through the mucus layer.T he nanovehicles then adhere to the mucous membrane.F urthermore,t he BPQDs degrade rapidly into nontoxicP O 4 3À and acidic H + ,t hereby promoting the dissociation of PEGylated CS nanospheres, accelerating the release of AM, decreasing the vitality of biofilms for ease of eradication. Our results reveal that drug delivery mediated by BPQDs is af easible and desirable strategy for precision medicine and promising for the clinical therapyo fCOPD.

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