In the present study, we investigated the effect of participants' mood on true and false memories of emotional word lists in the Deese-Roediger-McDermott (DRM) paradigm. In Experiment 1, we constructed DRM word lists in which all the studied words and corresponding critical lures reflected a specified emotional valence. In Experiment 2, we used these lists to assess mood-congruent true and false memory. Participants were randomly assigned to one of three induced-mood conditions (positive, negative, or neutral) and were presented with word lists comprised of positive, negative, or neutral words. For both true and false memory, there was a mood-congruent effect in the negative mood condition; this effect was due to a decrease in true and false recognition of the positive and neutral words. These findings are consistent with both spreading-activation and fuzzy-trace theories of DRM performance and have practical implications for our understanding of the effect of mood on memory.
In the present experiment, we investigated whether warnings provided at the time of retrieval would reduce emotional false memories in the Deese-Roediger-McDermott (DRM) paradigm. The provision of retrieval warnings allowed us to test specific predictions based on the associative theories (e.g., Activation-Monitoring Theory; AMT) and Fuzzy-Trace Theory (FTT) that have been used to account for false memories in the DRM paradigm. Participants were randomly assigned to either a no-warning group or a retrieval-warning group. In each group, mood-induction procedures were used to elicit a positive, negative, or neutral mood and participants were then presented with word lists comprised of positive, negative, or neutral words. Retrieval warnings reduced false recognition, regardless of the valence of the to-be-remembered information or participants' mood. Consistent with the associative theories' predictions, within the warning condition, positive moods yielded greater false recognition for positive critical lures, and negative moods yielded greater false recognition for negative critical lures, compared to neutral moods. These findings have important practical implications for our understanding of the effect of mood on memory.
When tested in the Deese-Roediger-McDermott paradigm, children typically exhibit fewer false memories than do adolescents or adults. Here, participants' moods and the valence of word lists were manipulated to explore the mechanism responsible for this developmental reversal in memory performance. Children (7- to 8-year-olds), adolescents (11- to 12-year-olds), and young adults (18- to 22-year-olds; N = 270) were assigned to one of three induced mood conditions and were presented with emotional word lists. In negative moods, adolescents and adults falsely recalled more negative information than did children, showing the typical developmental reversal effect. This effect, however, was eliminated when participants were in positive moods. The findings provide support for associative-activation theory and have important implications for our understanding of the development of emotional false memories.
Y-box binding proteins, belonging to a family of multifunctional proteins conserved from bacteria to human, are involved in transcriptional and translational regulation of various genes, mRNA alternative splicing, DNA replication and repair, as well as cell proliferation. A typical Y-box binding protein contains three structure domains, namely the N-terminal domain, the hydrophilic C-terminal domain and the conserved cold shock domain (CSD) which binds strongly to inverted CCAAT box found in different promoters and determines protein function.Y-box binding proteins may play an important physiological role in cell proliferation.For example, the human Y-box protein 1 (YB-1) may be repressed in the oncogenic phosphoinositide 3-kinase (PI3K) pathway. In addition, it may also act as a negative regulator of p53. It has been demonstrated that YB-1 represses transcription of the p53 promoter in a sequence-specific manner using specifically reporter assays. This implies that YB-1 may, in some situations, protect cells from p53-mediated apoptosis, indicating that YB-1 may be a good target for the development of a new therapeutics.The function of Y-box binding protein and its effect on carcinogenesis are summarized in the paper. We hope to further explore the functional roles of Y-box binding protein, and provide some helpful lines and suggestions for tumor control.
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