A new liposomal carrier embedded with a ratiometric fluorescent probe PNO is prepared. The integrated liposomes (PNO‐LIPs) exhibit blue fluorescence in serum. Triggered by the thiols exogenously or endogenously, PNO‐LIPs collapse with a burst drug release and a concurrent fluorescence change from blue to green. Furthermore, DOX‐loaded PNO‐LIPs improve the intracellular drug bioavailability.

Three new hydroxyl-substituted Schiff-bases containing ferrocenyl moieties were synthesized, and their antioxidant and anticancer activities were evaluated. Among the synthesized hydroxyl-substituted Schiff-bases, compound 1 containing both ferrocenyl and o-dihydroxyl groups exhibits the highest antioxidant and anticancer activities. Flow cytometric analysis showed that compound 1 is capable of disturbing the cancer cell cycle and inducing more cells to be arrested in G2 phase. The excellent biological activities of compound 1 are attributed to the presence of both ferrocenyl and o-dihydroxyl groups. The ferrocenyl moiety has dual functions in compound 1, i.e., increasing the lipophilicity and lowering the redox potentials of o-dihydroxyl groups. In addition, compound 1 could reversibly bind with HSA mainly via a mechanism involving the formation of complexes, in which hydrophobic interaction is the main acting force. Thus, compound 1 containing both ferrocenyl and o-dihydroxyl groups is a potential antioxidant with anticancer activity.