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Significance and Impact of the Study: The potential harm of Vibrio parahaemolyticus existing in biofilm on public health cannot be neglected. It is of great significance to apply lactic acid bacteria (LAB) as a safe biological strategy to control the pathogenicity and drug resistance of pathogens enhanced by biofilms. This work mainly evaluated the anti-biofilm effects of one strain of kefir-derived LAB on V. parahaemolyticus. The results exhibited that Lactobacillus paracasei L10 could effectively inhibit biofilm formation and eradicate established biofilms of V. parahaemolyticus. Our findings support that L. paracasei L10 has the potential to be applied as a natural and effective anti-biofilm agent to control the contamination and infection of V. parahaemolyticus.

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