We have established 51 solid tumor and 10 ALL in vivo models. The models identify vincristine and cyclophosphamide as having broad-spectrum activity. The PPTP tumor panels appear to generally recapitulate the activity of these agents against specific childhood cancers and to have the potential for identifying novel agents having significant clinical activity.

The photocatalytic performance of the star photocatalyst g-C3N4 was restricted by the low efficiency because of the fast charge recombination. The present work developed a facile in situ method to construct g-C3N4/g-C3N4 metal-free isotype heterojunction with molecular composite precursors with the aim to greatly promote the charge separation. Considering the fact that g-C3N4 samples prepared from urea and thiourea separately have different band structure, the molecular composite precursors of urea and thiourea were treated simultaneously under the same thermal conditions, in situ creating a novel layered g-C3N4/g-C3N4 metal-free heterojunction (g-g CN heterojunction). This synthesis method is facile, economic, and environmentally benign using easily available earth-abundant green precursors. The confirmation of isotype g-g CN heterojunction was based on XRD, HRTEM, valence band XPS, ns-level PL, photocurrent, and EIS measurement. Upon visible-light irradiation, the photogenerated electrons transfer from g-C3N4 (thiourea) to g-C3N4 (urea) driven by the conduction band offset of 0.10 eV, whereas the photogenerated holes transfer from g-C3N4 (urea) to g-C3N4 (thiourea) driven by the valence band offset of 0.40 eV. The potential difference between the two g-C3N4 components in the heterojunction is the main driving force for efficient charge separation and transfer. For the removal of NO in air, the g-g CN heterojunction exhibited significantly enhanced visible light photocatalytic activity over g-C3N4 alone and physical mixture of g-C3N4 samples. The enhanced photocatalytic performance of g-g CN isotype heterojunction can be directly ascribed to efficient charge separation and transfer across the heterojunction interface as well as prolonged lifetime of charge carriers. This work demonstrated that rational design and construction of isotype heterojunction could open up a new avenue for the development of new efficient visible-light photocatalysts.

Person re-identification has achieved great progress with deep convolutional neural networks. However, most previous methods focus on learning individual appearance feature embedding, and it is hard for the models to handle difficult situations with different illumination, large pose variance and occlusion. In this work, we take a step further and consider employing context information for person search. For a probe-gallery pair, we first propose a contextual instance expansion module, which employs a relative attention module to search and filter useful context information in the scene. We also build a graph learning framework to effectively employ context pairs to update target similarity. These two modules are built on top of a joint detection and instance feature learning framework, which improves the discriminativeness of the learned features. The proposed framework achieves state-of-the-art performance on two widely used person search datasets.

SUMMARY Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)—many of which are refractory to current standard-of-care treatments—from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer.

To develop efficient visible light driven photocatalysts for air purification, we constructed a novel semimetal−semiconductor Bi−Bi 2 MoO 6 (Bi−Mo) nanohybrid via the in situ deposition of Bi nanoparticles on the surface of Bi 2 MoO 6 microspheres. In this strategy, the Bi 3+ ions were in situ reduced to metallic Bi particles by glucose during in hydrothermal process. The XRD, XPS, SEM, TEM, UV−vis, DRS, PL spectra, and surface photovoltage were employed to explore the structural and optical properties. The assynthesized Bi−Bi 2 MoO 6 nanohybrid was applied in photocatalytic removal of NO in air. The results indicated that the amount of reductive glucose not only exerted a pivotal effect on the morphological structure but also affected the photocatalytic capability of the Bi−Bi 2 MoO 6 nanohybrid. The optimized Bi−Mo-50 hybrids exhibited exceptionally high visible-light photocatalytic performance with a NO removal ratio up to 68.1%, far outperforming other decent photocatalysts, like BiOBr (21.3%), C-doped TiO 2 (21.8%), N-doped TiO 2 (36.5%), N-doped (BiO) 2 CO 3 (43.5%), and g-C 3 N 4 (32.7%). This drastically enhanced photocatalytic capability was ascribed to the cocontributions of the enhanced light absorption and the improved separation efficiency of the charge carriers owing to the surface plasmon resonance (SPR) induced by Bi metal. The Bi metal performs as noble metal-like cocatalyst for promoting the photocatalysis efficiency. Based on the DMPO-ESR spin trapping, the active species generated from Bi/Bi 2 MoO 6 under visible light were • OH radicals. The Bi/Bi 2 MoO 6 produced more • OH radicals contributing to strengthen oxidation ability in comparison with that of the pristine Bi 2 MoO 6 . In addition, this advanced Bi/Bi 2 MoO 6 nanohybrid also exhibited high photochemical stability under repeated irradiation. This work demonstrated the feasibility of utilizing economical Bi element as a cocatalyst to substitute the precious noble metals to advance the photocatalysis efficiency.