Dequalinium chloride is a quaternary ammonium compound used for the treatment of infected skin and mucosal lesions. Its influence on the healing of incisional wounds in rat skin has been studied by a tensiometric technique. The breaking load was significantly lower in wounds that had been exposed to an aqueous solution of dequalinium chloride than those exposed to distilled water. The concentrations of dequalinium chloride were well below those used in clinical practice. The results obtained from incisional wounds are probably valid also for open wounds. The results are correlated with the microcirculatory disturbances demonstrated in previous studies. This suggests that the use of dequalinium chloride in treating human wounds should be re-evaluated.

200 patients with primary impetigo were studied. Staphylococcus aureus was the only organism isolated in 72.5%, beta-hemolytic streptococci, group A, in 10%, and both pathogens in 15%. 17 of the 50 streptococcal isolates were typed serologically; 11 of these belonged to potentially nephritogenic types. A majority of these cases had identical strains in the nose and throat. Hence, the primary source of skin streptococcal in this study may be the nasopharynx. Uncomplicated cases were treated with topical antibiotics, and oral antibiotics were added in 22 cases with extensive lesions, fever or a concurrent throat infection. None of the 200 patients developed acute glomerulonephritis and urinary analyses were normal at follow-up after 3 weeks.

is not availeble.