At present, with the development of an aging society and an increase in the number of elderly people, in order to ensure the ability and enthusiasm of the elderly to live independently, it is necessary to ensure that they can understand the world in a normal way. More and more elderly people have cognitive impairment, and virtual reality (VR) technology is more effective in cognitive diagnosis and treatment than traditional methods. This review article describes some studies on cognitive diagnosis and training for the elderly, and puts forward some suggestions for current studies, in the hopes that VR technology can be better applied to cognitive diagnosis and training.

The high-throughput extraction of quantitative imaging features from medical images for the purpose of radiomic analysis, i.e., radiomics in a broad sense, is a rapidly developing and emerging research field that has been attracting increasing interest, particularly in multimodality and multi-omics studies. In this context, the quantitative analysis of multidimensional data plays an essential role in assessing the spatio-temporal characteristics of different tissues and organs and their microenvironment. Herein, recent developments in this method, including manually defined features, data acquisition and preprocessing, lesion segmentation, feature extraction, feature selection and dimension reduction, statistical analysis, and model construction, are reviewed. In addition, deep learning-based techniques for automatic segmentation and radiomic analysis are being analyzed to address limitations such as rigorous workflow, manual/semi-automatic lesion annotation, and inadequate feature criteria, and multicenter validation. Furthermore, a summary of the current state-of-the-art applications of this technology in disease diagnosis, treatment response, and prognosis prediction from the perspective of radiology images, multimodality images, histopathology images, and three-dimensional dose distribution data, particularly in oncology, is presented. The potential and value of radiomics in diagnostic and therapeutic strategies are also further analyzed, and for the first time, the advances and challenges associated with dosiomics in radiotherapy are summarized, highlighting the latest progress in radiomics. Finally, a robust framework for radiomic analysis is presented and challenges and recommendations for future development are discussed, including but not limited to the factors that affect model stability (medical big data and multitype data and expert knowledge in medical), limitations of data-driven processes (reproducibility and interpretability of studies, different treatment alternatives for various institutions, and prospective researches and clinical trials), and thoughts on future directions (the capability to achieve clinical applications and open platform for radiomics analysis).

The COVID-19 coronavirus has spread rapidly around the world and has caused global panic. Chest CT images play a major role in confirming positive COVID-19 patients. The computer aided diagnosis of COVID-19 from CT images based on artificial intelligence have been developed and deployed in some hospitals. But environmental influences and the movement of lung will affect the image quality, causing the lung parenchyma and pneumonia area unclear in CT images. Therefore, the performance of COVID-19’s artificial intelligence diagnostic algorithm is reduced. If chest CT images are reconstructed, the accuracy and performance of the aided diagnostic algorithm may be improved. In this paper, a new aided diagnostic algorithm for COVID-19 based on super-resolution reconstructed images and convolutional neural network is presented. Firstly, the SRGAN neural network is used to reconstruct super-resolution images from original chest CT images. Then COVID-19 images and Non-COVID-19 images are classified from super-resolution chest CT images by VGG16 neural network. Finally, the performance of this method is verified by the pubic COVID-CT dataset and compared with other aided diagnosis methods of COVID-19. The experimental results show that improving the data quality through SRGAN neural network can greatly improve the final classification accuracy when the data quality is low. This proves that this method can obtain high accuracy, sensitivity and specificity in the examined test image datasets and has similar performance to other state-of-the-art deep learning aided algorithms.

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