A combination of treatment strategies with two or more different mechanisms can together prevent cancer progression. In this paper, we present a combination of strategies with siRNA interference-induced gene silencing, photothermal therapy and mesoporous drug delivery methods to cure cancer. First we synthesize oil-soluble copper sulfide nanoparticles, which are modified with mesoporous silica and (3-Amino-propyl)triethoxysilane (APTES), then use it as siRNA carrier to achieve siRNA transmission. At the same time, mesopores can also be used for drug delivery. Our results suggest that the copper sulfide nanomaterial loaded with siRNA and Adriamycin entered the cell successfully, and the composite can kill cancer cells effectively.[a] W.
Human motion recognition is playing an increasingly important role in modern society. Direct recognition of complex motions has great limitations, so we usually study basic motions first. The key to the establishment of the basic motion set is how to determine the number of basic motions. Sum of the Squared Errors Distribution (SSED) is therefore proposed to determine the number of clustering classes of Self Organizing Maps (SOM). Secondly, the Weighted Tangent Segmentation (WTS) is also proposed to segment complex motions into simple ones, and the sequence with the time stamp is generated. Finally, Back Propagation with the time stamp (BPTS) is proposed to classify the simple motions according to the basic motion set, and the complex motion is recognized according to the time stamp. The motions of human upper limbs are used to verify the effectiveness of this method. SSED determines that the number of clusters of human upper limb motion is 10. The experimental results show that the correct segmentation rate (CSR) is 98.13%. The recognition rate of basic motions is 98.67% and 99.33% in user independent (UI) and user dependent (UD) experiments, respectively. The recognition rate of complex motions is 96.37%. Experiments on UI and UD recognitions verified the effectiveness of our algorithm. Compared with other recognition algorithms, the complex motion recognition method proposed in this paper has better recognition performance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.