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A series of N‐phenyl and N‐pyridinyl‐5‐(trifluoromethyl)‐pyrazole carboxamide derivatives (T1–T25) were designed and synthesized. Bioassay results indicated that antifungal and antibacterial activities of title compounds could be obviously improved by placing trifluoromethyl on the 5‐position of the pyrazole ring and substituted 4‐pyridinyl at the amine side of the amide bond. The EC50 values of T3 against Gibberella zeae, Cytospora mandshurica, and Fusarium oxysporum were 14.7, 21.1, and 32.7 μg/mL, respectively, better than hymexazol (30.2, 47.3, and 42.5 μg/mL) and carboxin (34.2, >200, and >200 μg/mL). And the EC50 values of T6, T11, T12, T15, T18, T19, T23, and T25 against rice bacterial leaf blight were 17.0, 21.8, 21.9, 18.6, 16.8, 25.9, 9.4, and 24.4 μg/mL, respectively, much better than bismerthiazol (70.5 μg/mL).

To deepen our understanding of the aerodynamics by which hummingbirds use flexible wings to hover efficiently during flapping flight, a three-dimensional wing model with dynamic morphing was developed according to the morphological and kinematic data of a hovering hummingbird’s wing. Navier-Stokes equations were solved on a dynamically deforming grid to study wing aerodynamics. In numerical simulations, boundary-based smoothing and overset methodologies were used in combination to update the interior nodes of cells in the computational domain, allowing those nodes to accommodate the motion of the flexible wall. This study showed that the leading edge vortex (LEV) attached to the wing was stable during the downstroke but extremely unstable and shed continuously during the upstroke. In the results of the downward stroke, the different vortices separated from the surface and formed a vortex ring. The difference is that the leading edge vortex induced a vortex ring near the root and a smaller and weaker vortex ring near the wingtip during the upstroke. A significant enhancement in aerodynamic forces was found during the downstroke, along with a large number of power consumptions. We found that the asymmetry in the time-averaged vertical force between the two half strokes was 3.5, and the value was higher than that reported earlier. Aerodynamic force coefficients and efficiency matched well with those of another hummingbird wing (the ruby-throated hummingbird). It is worth noting that hummingbirds can maintain a similar wingtip speed by flapping their wings, but different strategies are adapted to hover efficiently due to the differences in size and body weight. The results of this study help to better understand the aerodynamics of the hovering hummingbird.

Ah ighly efficient Pd 0 -catalyzed 6-endo-trig Heck cyclization reactionh as been developed for the construction of 2-fluoroalkyl quinolines, which are importants tructural motifs for bioactive molecules. This process offers broad substrate scope, with excellent 6-endo selectivity,a nd affords quinoline derivativesi nm oderate-to-excellent yields.

Wingtip slots, where the outer primary feathers of birds split and spread vertically, are regarded as an evolved favorable feature that could effectively improve their aerodynamic performance. They have inspired many to perform experiments and simulations as well as to relate their results to aircraft design. This paper aims to provide guidance for the research on the aerodynamic mechanism of wingtip slots. Following a review of previous wingtip slot research, four imperfections are put forward: vacancies in research content, inconsistencies in research conclusions, limitations of early research methods, and shortage of the aerodynamic mechanism analysis. On this basis, further explorations and expansion of the influence factors for steady state are needed; more attention should be poured into the application of flow field integration method to decompose drag, and evaluation of variation in induced drag seems a more rational choice. Geometric and kinematic parameters of wingtip slot structure in the unsteady state, as well as the flexibility of wingtips, should be taken into account. As for the aerodynamic mechanism of wingtip slots, the emphasis can be placed on the study of the formation, development, and evolution of wingtip vortices on slotted wings. Besides, some research strategies and feasibility analyses are proposed for each part of the research.