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Biopolymer scaffolds which made from various ratios of gelatin blended with carboxymethylcellulose (CMC) were studied. The scaffolds were fabricated to porous structure via freeze drying process and crosslinked to induce conjugation of free amide and carboxyl groups in protein structures by using thermal crosslinking techniques. The mechanical properties of the scaffolds were characterized by experimental procedure. In order to evaluate the modeling, we described the stress-strain behavior of the scaffolds by fitting the data to a neo-Hookean model. Results shown that models which evaluated CMC blended gelatin scaffold in the ratio of 80 and 20 of gelatin and CMC occurred in the highest average in shear modulus which was 11.46 kPa compared to other blended scaffolds. Gelatin scaffold with 10, 30 and 40% of CMC showed dramatically decreased in the shear modulus which were 2.12, 1.73 and 0.85 kPa, respectively compared to pure gelatin scaffold with significant different. These results showed the possibility of using CMC as a low cost material to combine with biopolymers for using in tissue engineering applications.

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Objectives Basic Life Support (BLS) should be taught to everyone; however, there is a lack of Automated External Defibrillation (AED) trainers in Thailand due to the cost of the imported equipment. An AED trainer, manikin, and manikin controller system was locally developed which can display training results to help reduce the cost. Methods This is a descriptive study of a locally developed controller and feedback system, the Chiang Mai AED trainer and manikin. The controller was examined by 5 BLS instructors using a 10-point scale questionnaire consisting of 3 questions to evaluate the efficacy of the device. Correlation among BLS instructors was also calculated. Results The controller and feedback system for the Chiang Mai AED trainer and manikin worked appropriately as intended. The instructor set up either a ‘shock advised’ or a ‘no shock advised’ scenario for 2 two-minute chest compressions. The AED trainer responded promptly when the electrode pads were attached to the manikin. The controller was also able to display compression depth, compression speed, chest recoils, rescue breaths, and time to first defibrillation. Evaluation of the controller using a 10-point scale resulted in a median of 27 (interquartile range 26-29) out of 30. Intraclass correlation was 0.97 (95% confidence interval 0.90-0.99, p < 0.001). Conclusions The controller for the Chiang Mai AED trainer and manikin is effective for use in BLS training. Chiang Mai Medical Journal 2021;60(1):87-98. doi 10.12982/CMUMEDJ.2021.08

There is limited documentation of using fluorescence images in oral potentially malignant disorders (OPMDs) and oral cancer screening through the field of teledentistry. This study aims to develop and evaluate the validity and reliability of the intraoral camera with the combination method of autofluorescence and LED white light used for OPMDs and oral cancer screening in teledentistry. The intraoral camera with fluorescent aids, which uses a combined method of both autofluorescence and LED white light, was developed before the device was evaluated for validity and reliability as a OPMDs screening tool for teledentistry. All lesions of thirty-four OPMD patients underwent biopsy for definitive diagnosis and were examined by an oral medicine specialist. Both images under autofluorescent and LED white light mode captured from the device were sent online and interpreted for the initial diagnosis and dysplastic features in addition to being compared to the direct clinical examination and histopathological findings. The combination method was also compared with autofluorescence method alone. The device provided good image quality, which was enough for initial diagnosis. Using the combination method, sensitivity, specificity, PPV, and NPV of the device via teledentistry were 87.5%, 84.6%, 63.6%, and 95.7%, respectively, which were higher than autofluorescence method alone in every parameter. The concordance of dysplastic lesion was 85.29% and 79.41% for category of lesion. The validity and reliability results of the combination method for the screening of dysplasia in OPMDs were higher than autofluorescent method alone. The intraoral camera with fluorescent aids for the OPMDs screening can be utilized for screening via teledentistry.