Identification of Shear Modulus of Gelatin Blended with Carboxymethylcellulose Scaffolds Using Curve Fitting Method from Compressive Test

Wiwatwongwana, Fasai; Khunathon, Yotthana; Rangsri, Wetchayan; Promma, Nattawit; Pattana, Somchai

doi:10.5539/jmsr.v1n4p106

Cited by 9 publications

(11 citation statements)

References 16 publications

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“…These measured values correspond well with previously reported compressive moduli for the same or similar formulations of each polymer (Armani et al 1999, Clapper and Guymon. 2007, Wiwatwongwana et al 2012). Of these polymers, the soft crosslinked PEG and gelatin most closely matched the range of moduli identified for the neural retina.…”

Section: Resultsmentioning

confidence: 99%

Mechanical properties of murine and porcine ocular tissues in compression

Worthington

Wiley

Bartlett

et al. 2014

Experimental Eye Research

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Sub-retinal implantation of foreign materials is becoming an increasingly common feature of novel therapies for retinal dysfunction. The ultimate compatibility of implants depends not only on their in vitro chemical compatibility, but also on how well the mechanical properties of the material match those of the native tissue. In order to optimize the mechanical properties of retinal implants, the mechanical properties of the mammalian retina itself must be carefully characterized. In this study, the compressive moduli of eye tissues, especially the retina, were probed using a dynamic mechanical analysis instrument in static mode. The retinal compressive modulus was lower than that of the sclera or cornea, but higher than that of the RPE and choroid. Compressive modulus remained relatively stable with age. Conversely, apparent retinal softening occurred at an early age in mice with inherited retinal degeneration. Compressive modulus is an important consideration for the design of retinal implants. Polymer scaffolds with moduli that are substantially different than that of the native tissue in which they will ultimately reside will be less likely to aid in the differentiation and development of the appropriate cell types in vitro and will have reduced biocompatibility in vivo.

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Section: Resultsmentioning

confidence: 99%

Mechanical properties of murine and porcine ocular tissues in compression

Worthington

Wiley

Bartlett

et al. 2014

Experimental Eye Research

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“…The uniaxial compressive test for each scaffold condition was performed by using universal testing machine (UTM) with compression rate of 0.1 mm/minute in dry condition at 25°C to collect load and displacement data from the experiment which provided stress-strain relation [17]. It was used to prove that at the same testing condition, the Blatz-Ko model could fit better than the Neo-Hookean model.…”

Section: B Mechanical Properties Identificationmentioning

confidence: 99%

Mechanical Properties Analysis of Scaffold Material Using Nonlinear Least Squares Fitting by Hyperelastic Model

Wiwatwongwana¹,

Promma²

2020

IJMMM

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Nowadays, the number of chronic wounds is on the rise. Wounds can caused by many problems such as disease, burn, ulceration, trauma and accident. Tissue engineering aims to produce porous scaffold biomaterials to regenerate damaged tissues to growth of new tissue. This research, gelatin was blended with Carboxymethylcellulose (CMC) in various conditions and fabricated to porous structure by using freezedrying method. All scaffolds were strengthen their structure by dehydrothermal crosslinking. Normally, the scaffold behavior is likely to be a foam-like hyperelastic material. Therefore, this research was selected Blatz-Ko model to describe the material behavior that acts as a foam rubber. This model could apply with both cases of compressible and incompressible material. The mechanical characterization of the scaffold was investigated by compressive test using universal testing machine (UTM). The experimental data obtained from the UTM was used to plot the stress-strain curve. The initial shear modulus of the material was identified by function derived from Blatz-Ko hyperelastic model using non-linear curve fitting method. The result revealed that Blatz-Ko model could fit curve at approximately 7% strain which was suitable for infinitesimal strain theory. The dehydrothermal treated scaffold with 90:10 gelatin/CMC ratio showed the highest shear modulus of 10.47±1.21 kPa. The structural collapse occurred in 60:40 gelatin/CMC scaffold. The physical characterization was done by using scanning electron microscopy (SEM) to investigate surface morphology and pore size of scaffolds. The results showed the appropriate pore size of the scaffold with average pore size of 117 µm to 197 µm. The 90:10 gelatin/CMC scaffold showed the biggest pore size.

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“…The compressive testing was performed by using universal testing machine (UTM, Zwick/Roell Z1.0) to collect load-deformation data from experimental test to obtain stress-strain information. The compression rate was 0.5 mm/minute in dry condition at 25 °C [20]. The tested gelatin/CMC scaffolds were divided into 5 mixtures which were 100/0, 90/10, 80/20, 70/30 and 60/40, respectively.…”

Section: A Geometry and Loading Conditionmentioning

confidence: 99%

Mechanical Properties Analysis of Gelatin/Carboxymethylcellulose Scaffolds

Wiwatwongwana¹,

Chaijit²

2019

IJMMM

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Gelatin blended with carboxymethylcellulose (CMC) scaffold was fabricated via freeze drying method. The various gelatin and CMC ratios were 100/0, 90/10, 80/20, 70/30 and 60/40, respectively. The mechanical characterization of the scaffold was done by compressive test using universal testing machine. The obtained data was used to determine compressive modulus and shear modulus which was analyzed from neo-Hookean model. The deformed scaffold and total strain energy time response were analyzed using finite element model (FEM). The scaffold G73T showed the highest value both compressive modulus (0.53±0.11 kPa) and shear modulus (1.02±0.11 kPa). The results were consistency with FEM that G73T showed the highest range of equivalent elastic strain and the highest value of total strain energy-time response. The results could imply the best condition for scaffold fabrication from mechanical analysis which might suitable for tissue engineering applications.

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Identification of Shear Modulus of Gelatin Blended with Carboxymethylcellulose Scaffolds Using Curve Fitting Method from Compressive Test

Cited by 9 publications

References 16 publications

Mechanical properties of murine and porcine ocular tissues in compression

Mechanical properties of murine and porcine ocular tissues in compression

Mechanical Properties Analysis of Scaffold Material Using Nonlinear Least Squares Fitting by Hyperelastic Model

Mechanical Properties Analysis of Gelatin/Carboxymethylcellulose Scaffolds

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