Population growth in an area is important for development and is a benchmark for an area to develop. The way to predict population growth is to use Data Mining. Data mining is able to analyze data into information. This study will discuss the amount of population growth in the District of Gunung Malela. The estimation technique that will be used is Multiple Linear Regression. This method was chosen because it can make an estimate/prediction by utilizing old data regarding population growth so that it can produce a pattern of relationships. This Multiple Linear Regression method aims to make the best predictions. The research data used is the population in the Gunung Malela sub-district in 2016-2020. Based on the research that has been done using the Multiple Linear Regression method, the results of the population growth are 40078 residents. This means that there is an additional population of 469 people in Gunung Malela District. The results of this study can be input to the Gunung Malela Sub-District Office to anticipate the rate of population growth and it can be concluded based on this study that the Multiple Linear Regression method can be used to estimate the population.