This research was conducted to determine how much physical workload and mental workload received by employees at PT. Woneel Midas Leathers, especially in the Quality Control (QC) department in carrying out their work. This research is a descriptive study, using a sample of 40 female employees who are the entire population of QC workers at PT. Woneel Midas Leathers. Data collection includes filling out the NASA-TLX questionnaire for mental workload analysis, and using employee physical data to calculate Body Mass Index (BMI) and pulse data calculated using the %CVL (Cardiovascular) method for physical workload analysis. The results of the calculation of the physical workload calculated using the %CVL (Cardiovascullar) method with an average physical workload of 31.62 employees are included in the "Required Improvement" classification. The NASA-TLX classification value of the average employee WWL that has been obtained is 81.48. This shows that the average value of mental workload received by employees is in the "High" category. Based on the results of calculations using the statistical regression method using SPSS software, the Sig value is obtained. of 0.441 which indicates that between the two variables, namely the physical workload has no effect on the mental workload. Likewise, the ideal body weight does not affect the mental workload conditions received by each employee.