Provides information of the structure, examples, and safety considerations for compounds that can produce explosive peroxides.

Notes 2051 tin in boiling acid solution.1 It was assumed that this coloration was due to the formation of ß-(5pyrrolenyl) -isatin or pyrrole blue B. Recently it has been shown,2 however, that pyrrole blue B in glacial acetic acid has a maximum absorption at 680-690 µ while the maximum absorption in the microreaction was observed in the range for 510-560 m/i. For a more exact comparison the absorption spectrum of the color reaction was determined in a Hilger-Nutting spectrophotometer. The resulting curve A in Fig. 1 is quite different from the spectrum of pyrrole blue B, shown in curve B. The logarithm of specific extinction K is calculated per grams of pyrrole per liter. Thus the compound formed in the color reaction is certainly not pyrrole blue B but seems to be its decomposition product which also forms when solutions of pyrrole blue B are standing for some time. It has been indicated2 that the decomposition product has an absorption maximum at 520 µ.The author is greatly indebted to the Chemistry Department of the University of Michigan for the permission to use a spectrophotometer and to Dr. F. F. Blicke for the supply of pyrrole.

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The first practical synthesis of the estrogen hexestrol (I), C2H6 h0-^h-ch-qh c2h6 I discovered by Dodds, et al. (1), was reported in 1940 by Docken and Spielman (2) and independently by Peak and Short (3) and Bernstein and Wallis (4).This synthesis involved a Wurtz-type coupling of anethole hydrobromide (II)The yield of the meso isomer of hexestrol dimethyl ether by this reaction was 15 to 20% using metals such as magnesium and sodium, and somewhat lower (6%) employing a Grignard reagent such as methylmagnesium iodide (5). In 1943 Kharasch and Kleiman (6) described an improved Grignard coupling proce-