Esomeprazole is an inhibitor of the proton pump that reduces gastric acidity and is used in indigestion treatment; Esomeprazole is a promising treatment for tumors, such as melanoma and B cell leukemia, through several mechanisms, including rapid cellular acidification and activation of many types of caspase enzymes, which in turn lead to the activation of cellular apoptosis This work was designed to assess the toxicity of the (Esomeprazole) on (HeLa cell line) in vitro at concentrations starting from one -ten thousand μg/ milliliter and compared with cytotoxicity of vincristine and methotrexate at concentrations between one -ten thousand μg/ milliliter In 3 incubation periodsThe results showed that the cellular toxicity of one μg / milliliter was a lot of more than the cellular toxicity of ten and a hundred μg / milliliter. The results additionally showed that toxicity of esomeprazole was considerably more than vincristine and methotrexate on HLA cells at seventy two hours.

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The present study assessed the effects of O-anisidine hydrochloride and the ameliorating effect of Quercetin dihydrate in laboratory rats. Sixteen male and thirty two female rats (Rattus norvegicus) were used and divided into eight equal groups of two male and four female rats each. The results revealed that the treatment with Oanisidine hydrochloride for 30 days (T1, T2 and T3 groups) caused significant decrease in the males body weights, sperm count, individual and massive sperm motility, testes weights, and epididymis weights as compared with control and (T4, T5, T6 and T7) groups at (P≤0.05).When Quercetin dihydrate was offered as an ameliorating agent, it showed a significant ameliorating effect by increasing the body weights, sperm count, individual and massive sperm motility, testes weights, and epididymis weights . When Quercetin dihydrate was offered alone in the ration of the sixth treated group (T6), it caused clear significant ameliorating effect on all sperm parameters comparing with all treated groups and the sperm count was even significantly higher than that of control group while the other aspects were similar to those of control group at (P≤0.05). Beside, O-anisidine caused significant decrease in the number of pregnant females, number of delivered litters, weight of litters and sex ratio, and it prevented the pregnancy from being occurred in the group where both male and females are treated with it (T1). When Quercetin was mixed with Oanisidine in the ration of (T7), it significantly ameliorated the pregnancy chances, 251 number of litters and the sex ratio as compared with the other groups but it didn't reach to significant level with control group at (P≤0.05).

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