Study the Protective Role of Quercetin Against O-Anisidine Toxicity on Some Hematological Parameters of Laboratory Male Rats (Rattus Norvegicus).

Al-Uboody, Wissam Sajid Hashim; Al-Diwan, Muhammed Ali

doi:10.33762/bvetr.2015.102443

Cited by 4 publications

(2 citation statements)

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“…It serves as a scaffold for the tubules and plays a crucial role in supporting the spermatogenesis process. In normal conditions, the TBM is thin and well organised (Al-Uboody, 2015). However, exposure to certain toxic substances such as cadmium can result in the thickening of the TBM, as seen in plates 4.1b and 4.2b above.…”

Section: Discussionmentioning

confidence: 99%

Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats

Ehiremen,

Iyare,

Omorodion

2024

JOHASAM

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Cadmium is a harmful heavy metal that is widely distributed in the environment. This study aimed to investigate the effects of Annona muricata seed extract on cadmium-induced testicular toxicity in adult male Wistar rats. A total of 35 adult male Wistar rats were randomly divided into five groups (A–E)) of 7 rats each. Group A (the control group) received distilled water only; group B-E received 2 mg/kg of cadmium (S.C.) and 100 mg/kg body weight of Annona muricata, 2 mg/kg of cadmium (S.C.) and 200 mg/kg body weight of Annona muricata, and 2 mg/kg of cadmium and 300 mg/kg body weight of Annona muricata respectively. After 17 days of treatment, the animals were brought out, weighed, and sacrificed via cranial dislocation. Testicular, seminal fluid, and blood samples were taken for examination. SPSS version 21 was used in the analysis. The results of the study showed that the Annona muricata aqueous seed extract increased the levels of superoxide dismutase (SOD) and catalase (CAT) in a dose-dependent manner compared to the cadmium-only group. The relative weight of the testis increased significantly in the treated groups compared to the cadmium-only group. Testosterone levels also increased significantly (P < 0.05) in the treated groups compared to the group A (control). The extract showed a significant protective effect against cadmium-induced toxicity, as indicated by the higher testosterone levels in treated groups compared to the untreated group. Medicinal plants like Annona muricata can be used to treat heavy metal toxicity in traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats

Ehiremen,

Iyare,

Omorodion

2024

JOHASAM

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“…(11) Que and its derivatives are of the most powerful antioxidants found in plants and contains several OH groups in its structure, which may further contribute to photodegradation. (8,12) It is one of more than 4000 plant phenolics that are naturally available, (13) in many vegetables, fruits and drinks ingested from the daily diet, (14) including onions, broccoli, apples, berries, (15) and citrus fruits, (9) it is ubiquitously present in wine and tea. (16,17) Que is well known for its vasodilator, antihypertensive effects, antiatherosclerotic, antiobesity, antihypercholesterolemic, and antidiabetic activities.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Bioavailability of Quercetin by Concomitant Administration with Enzyme Inhibitor

Abdulhameed¹,

Hassan²,

Alwafi³

et al. 2022

Journal of Pharmaceutical Negative Results

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Background: Quercetin is a food supplement with multiple biological activities including antihypertensive, vasodilator effects, antiobesity, antihypercholesterolemic, antiatherosclerotic and other activities, it is available in wide range of dietary supplement and daily food intake, after oral ingestion, quercetin is metabolized by intestinal enzymes and absorbed by the duodenum, then be transported to the liver where is transformed into its glucuronidated, methylated and sulfo-substituted metabolites.Aim of Study: Boosting the bioavailability of Quercetin by enzyme inhibitor effect of ketoconazoleMethod: 10 apparently healthy adult, male (5) and female (5) were grouped A and B, with a 1-week wash-period, Group A received Quercetin 1000 mg, group B received Quercetin 1000 mg and Ketoconazole 400 mg, and 15 blood samples are collected on the following timing 0, 0.5 - 12.5 by 1 hour interval and other by hour 24 for HPLC Assay.Results: Concurrent ketoconazole administration with Quercetin significantly improves the mean plasma concentration under the curve from zero time to infinity (AUC0–∞) by 176% (403.41 ± 62.28 vs. 228.51 ± 28.67 μg.h/mL; P <0.0001) and prolonged time to complete elimination (44.66 ± 9.17 vs. 12.93 ± 1.4 hr.; P <0.0000) compared with Quercetin alone.Conclusion: Bioavailability of Quercetin will be increased by its administration together with ketoconazole, due to enzyme inhibiting effect of ketoconazole which delay elimination and increase the AUC of Quercetin.

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Physiological Scrutiny to Appraise a Flavonol Versus Statins

Al-Uboody

Yasin

Jumaa

et al. 2023

Biomed. Pharmacol. J.

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Because of the vast use of statins to control and treat hyperlipidemia, this study was set to compare the most common statins Atorvastatin and Simvastatin with the flavonol Kaempferol considering the unwilled collateral effects of them. Sixty adult albino male rats were allocated into five groups of twelve members to each. It is obvious based on the results that Atorvastatin could cause significant declination in the hemoglobin, hematocrit, platelets and leukocytes while simvastatin could cause a significant declination in leukocytes and platelets, on the other side; the kaempferol could not affect these values comparing with the control group. The lipid profile and the hepatic enzymes like Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) were significantly disturbed too in all groups and it was very clear that serum aminotransferases and alkaline phosphatase were significantly elevated in all groups except the Kaempferol comparing with control group at (P≤0.05). It is very obvious that kaempferol could ameliorate the lipid profile the antioxidant enzymes and the blood values in a manner which is better than those of statins.

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Study the Protective Role of Quercetin Against O-Anisidine Toxicity on Some Hematological Parameters of Laboratory Male Rats (Rattus Norvegicus).

Cited by 4 publications

References 0 publications

Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats

Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats

Enhancing the Bioavailability of Quercetin by Concomitant Administration with Enzyme Inhibitor

Physiological Scrutiny to Appraise a Flavonol Versus Statins

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