Objectives. The aim of our study was to determine the endothelial function in patients with chronic kidney disease (CKD), stage V (end-stage renal disease-ESRD), before and during a one-year observation after kidney allotransplantation. Patients and methods. We studied 40 patients with stabile graft function after their first kidney transplantation, including 21 females (mean age 41 ±12.5 yrs) and 19 males (mean age 43.6 ±13.3 yrs), treated already with hemodialysis because of ESRD. Results. After transplantation we observed significant decrease in serum creatinine concentrations (Cr) (7.32 ±2.07 mg/dl to 1.50 ±0.45 mg/dl at 6 months and 1.61 ±0.58 mg/dl after 12 months after transplantation). During 12 months we found changes only in plasminogen activator inhibitor-1 (PAI-1) levels. Von Willebrandt factor (vWF) levels remained unaltered during follow-up and total homocysteine (tHcy) concentration decreased, but this change was not statistically significant. There was no correlation between vWF and PAI-1 concentrations and other clinical and laboratory findings. Conclusions. In our study we did not find any improvement of endothelial function during the first year after kidney allotransplantation. The mean Cr concentration at the end of study was 1.6 mg/dl, which indicates the chronic kidney graft insufficiency. We conclude that despite kidney allotransplantation endothelial function is impaired like in CKD, but with more advanced abnormalities in the cardiovascular system.

Parathyroid adenoma injection is an alternative method of treatment for some patients resistant to treatment by means of vitamin D3 pulses or intravenous administration of calcitriol. The success of treatment is to a great extent determined by proper selection of patients and the taking of decisions when the period of secondary hyperparathyroidism is not very advanced.

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