The advancing of economic and technology in the last 1–2 centuries that characterized by industrialization, urbanization, and globalization have changed human lifestyle worldwide. Abundance of food and the ease of getting it, the availability of calorie-dense processed foods, changes in dietary patterns, and sedentary lifestyles force the rapid accretion of the incidence of obesity and non-communicable diseases such as type 2 Diabetes mellitus, cardiovascular diseases (CVD), and cancer. Non communicable diseases (NCDs) are the leading cause of death worldwide, and one of the major health challenges of the 21st century.1 In 2016, NCDs were responsible for 71% (41 million) of the 57 million deaths which occurred globally. The major NCDs responsible for these deaths included cardiovascular, cancers, chronic respiratory diseases, and diabetes.2 Many epidemiological, observational, and clinical studies have shown that nutrition, as the main environmental factor, plays a pivotal role in these high-cost degenerative diseases.

Abstract-The information of relationship between genetics and cancer in Indonesia, especially colon cancer, is still limited. This study aimed to determine the genetic pattern of colon cancer allele in Fatmawati Hospital, Jakarta -Indonesia. We conducted a case-control study of 40 colorectal cancer patients and 133 volunteers as controls. We observed CYP1A1*2A alleles using RFLP-PCR method. Three milliliters of blood was used to isolate DNA. Our observation showed of the genetic patterns CYP1A1*2A with the incidence of colorectal cancer showed 17 patients were variant-type homozygote and 12 patients were heterozygote type. In this research shown the common of genotyping type CYP1A1*2A of colorectal cancer from the patients are a homozygous variant type.