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-In Ethiopia, food production for a rapidly growing population from a continually shrinking farm size is a prime developmental challenge. Rising input costs, decline in soil quality, and buildup of insect pests, diseases and weeds have threatened the ecological and economic sustainability of crop production. To address those issues, intercropping of cereals with pulse crops could increase total grain production, provide diversity of products, stabilize yield over seasons, reduce economic and environmental risks common in monoculture systems, and thereby enhance sustainability. Here, mixed intercropping of wheat (Triticum aestivum L.) with faba bean (Vicia faba L.) was compared with sole culture of each species in 2002 and 2003 at Holetta Agricultural Research Center, in the central highlands of Ethiopia. The treatments were sole wheat at a seed rate of 175 kg ha −1 , sole faba bean at a seed rate of 200 kg ha −1 , and an additive series of 12.5, 25, 37.5, 50 and 62.5% of the sole faba bean seed rate mixed with the full sole wheat seed rate. Our results showed that mixed intercropping increased the land equivalent ratio by +3% to +22% over sole cropping. Increasing the faba bean seed rate in the mixture from 12.5 to 62.5% reduced wheat grain yield from 3601 kg ha −1 to 3039 kg ha −1 but increased faba bean grain yield from 141 kg ha −1 to 667 kg ha −1 . Sole culture grain yield exceeded mixed culture grain yield by +5 to +25% for wheat and by +172 to +1190% for faba bean. Nonetheless, we obtained the highest total grain yield of 4031 kg ha −1 , gross monetary value of US$ 823, system productivity index of 4629 and crowding coefficient of 4.70 when wheat at its full seed rate was intercropped with faba bean at a rate of 37.5%. On average, weed biomass was reduced from 40.4 g m −2 in sole wheat to 31.1 g m −2 in mixed culture and the chocolate spot disease score was reduced from 5.1 in sole faba bean to 3.4 in mixed culture. In conclusion, intercropping of wheat with faba bean may increase total yield and revenue, reduce weed and disease pressure, increase land-use efficiency, and thereby enhance sustainability of crop production in Ethiopian highlands. aggressivity / crowding coefficient / faba bean / land-use efficiency / intercropping / wheat

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African countries face key challenges in the deployment of GM crops due to incongruities in the processes for effective and efficient commercial release while simultaneously ensuring food and environmental safety. Against the backdrop of the preceding scenario, and for the effective and efficient commercial release of GM crops for cultivation by farmers, while simultaneously ensuring food and environmental safety, there is a need for the close collaboration of and the interplay between the biosafety competent authorities and the variety release authorities. The commercial release of genetically modified (GM) crops for cultivation requires the approval of biosafety regulatory packages. The evaluation and approval of lead events fall under the jurisdiction of competent national authorities for biosafety (which may be ministries, autonomous authorities, or agencies). The evaluation of lead events fundamentally comprises a review of environmental, food, and feed safety data as provided for in the Biosafety Acts, implementing regulations, and, in some cases, the involvement of other relevant legal instruments. Although the lead GM event may be commercially released for farmers to cultivate, it is often introgressed into locally adapted and farmer preferred non-GM cultivars that are already released and grown by the farmers. The introduction of new biotechnology products to farmers is a process that includes comprehensive testing in the laboratory, greenhouse, and field over some time. The process provides answers to questions about the safety of the products before being introduced into the environment and marketplace. This is the first step in regulatory approvals. The output of the research and development phase of the product development cycle is the identification of a safe and best performing event for advancement to regulatory testing, likely commercialization, and general release. The process of the commercial release of new crop varieties in countries with established formal seed systems is guided by well-defined procedures and approval systems and regulated by the Seed Acts and implemented regulations. In countries with seed laws, no crop varieties are approved for commercial cultivation prior to the fulfillment of the national performance trials and the distinctness, uniformity, and stability tests, as well as prior to the approval by the National Variety Release Committee. This review outlines key challenges faced by African countries in the deployment of GM crops and cites lessons learned as well as best practices from countries that have successfully commercialized genetically engineered crops.

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