PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consortium, including the European Society for Paediatric Oncology, two imaging biobanks, and three prominent European paediatric oncology units. The project is constructed as an observational in silico study involving high-quality anonymised datasets (imaging, clinical, molecular, and genetics) for the training and validation of machine learning and multiscale algorithms. The open cloud-based platform will offer precise clinical assistance for phenotyping (diagnosis), treatment allocation (prediction), and patient endpoints (prognosis), based on the use of imaging biomarkers, tumour growth simulation, advanced visualisation of confidence scores, and machine-learning approaches. The decision support prototype will be constructed and validated on two paediatric cancers: neuroblastoma and diffuse intrinsic pontine glioma. External validation will be performed on data recruited from independent collaborative centres. Final results will be available for the scientific community at the end of the project, and ready for translation to other malignant solid tumours.

In this article, we describe a workflow and tool that allows a flexible formation of hypotheses about text features and their combinations, which are significantly connected in time to quantitative phenomena observed in stock data. To support such an analysis, we combine the analysis steps of frequent quantitative and text-oriented data using an existing a priori method. First, based on heuristics, we extract interesting intervals and patterns in large time series data. The visual analysis supports the analyst in exploring parameter combinations and their results. The identified time series patterns are then input for the second analysis step, in which all identified intervals of interest are analyzed for frequent patterns co-occurring with financial news. An a priori method supports the discovery of such sequential temporal patterns. Then, various text features such as the degree of sentence nesting, noun phrase complexity, and the vocabulary richness, are extracted from the news items to obtain meta-patterns. Meta-patterns are defined by a specific combination of text features which significantly differ from the text features of the remaining news data. Our approach combines a portfolio of visualization and analysis techniques, including time, cluster, and sequence visualization and analysis functionality. We provide a case study and an evaluation on financial data where we identify important future work. The workflow could be generalized to other application domains such as data analysis of smart grids, cyber physical systems, or the security of critical infrastructure, where the data consist of a combination of quantitative and textual time series data.

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Linguistic insight in the form of high-level relationships and rules in text builds the basis of our understanding of language. However, the data-driven generation of such structures often lacks labeled resources that can be used as training data for supervised machine learning. The creation of such ground-truth data is a time-consuming process that often requires domain expertise to resolve text ambiguities and characterize linguistic phenomena. Furthermore, the creation and refinement of machine learning models is often challenging for linguists as the models are often complex, in-transparent, and difficult to understand. To tackle these challenges, we present a visual analytics technique for interactive data labeling that applies concepts from gamification and explainable Artificial Intelligence (XAI) to support complex classification tasks. The visual-interactive labeling interface promotes the creation of effective training data. Visual explanations of learned rules unveil the decisions of the machine learning model and support iterative and interactive optimization. The gamification-inspired design guides the user through the labeling process and provides feedback on the model performance. As an instance of the proposed technique, we present QuestionComb , a workspace tailored to the task of question classification (i.e., in information-seeking vs. non-information-seeking questions). Our evaluation studies confirm that gamification concepts are beneficial to engage users through continuous feedback, offering an effective visual analytics technique when combined with active learning and XAI.

This chapter surveys visualization techniques for frequent itemsets, association rules, and sequential patterns. The human is crucial in the process of identifying interesting patterns and thus, mining such patterns and visualizing them is important for the decision making. The complementary feedback loop that a user may use to refine parameters through inspecting the current mining results is broadly described as visual analytics. This survey identifies visual designs for patterns of each category and analyzes and compares their strengths and weaknesses systematically. The comparison and overview help decision-makers selecting the appropriate technique for their tasks and systems while knowing about their limitations.