Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp diomyopathy (CMP) is not an established concept yet, and reports on its epidemiology and clinical characteristics are scarce. Therefore, clinical characteristics of CO-induced CMP and its significance need to be elucidated.Stress-induced CMP, also known as takotsubo CMP, is a type of heart failure characterized by rapid reversibility and distinctive contraction patterns in the left ventricle. 13-16 It can be triggered by emotional events, and is found predominantly in postmenopausal women. 13,15 Takotsubo CMP occurs under the condition of catecholamine excess, as in exogenous epinephrine, pheochromocytoma, and acute neurologic disorders (eg, intracranial bleeding and cerebral infarction).
17-21There are a number of common factors between CO-induced CMP and takotsubo CMP, although the clinical features are not completely identical. Here, we investigate CO-induced CMP in terms of its epidemiology, clinical characteristics, and prognosis.arbon monoxide (CO) is an odorless, colorless, and nonirritating gas. 1,2 Even a small amount of CO exposure is possibly associated with organ damage and specific toxic effects. Acute CO poisoning is a major cause of mortality and morbidity worldwide. 1,2 According to previous reports, the main mechanism of CO toxicity is ischemic hypoxia secondary to hypoxemia. 1,3,4 Specifically, the heart is the major target organ of acute CO poisoning. 3 Cardiovascular manifestations demonstrated in previous reports include arrhythmia, pulmonary edema, heart failure, and myocardial infarction. 5-10 Cardiac failure was presented in patients who experienced acute CO poisoning. Background: Previous reports demonstrated mechanisms of cardiac toxicity in acute carbon monoxide (CO) poisoning. Still, none established CO-induced cardiomyopathy (CMP) as a clinical entity. The aim of this study is to investigate CO-induced CMP in patients with acute CO poisoning in terms of its epidemiology, clinical characteristics, and prognosis.