BACKGROUND AND PURPOSE: DW-MR spectroscopy can detect the diffusion coefficients of NAA, Cr, PCr, and Cho and can, therefore, provide some useful information. The aims of this study were to probe the mechanisms underlying the pathogenesis of MELAS and to see whether DW-MR spectroscopy is a useful technique for other diseases besides cerebral infarction.

To investigate the application of quantitative magnetic resonance imaging in the quantitative measurement of gadolinium deposition in the deep cerebellar nucleus (DCN) of rats.The absolute correlation coefficients between DCN T1 value and DCN gadolinium concentration, and DCN/ cerebrar cortex T1WI signal intensity ratio and DCN gadolinium concentration were 0.925 (P<0.001) and 0.849 (P<0.001).These results suggest that quantitative magnetic resonance imaging has a good expression of T1 relaxation time in the dentate nucleus region of cerebellum, which provides a basis for quantitative magnetic resonance estimation of clinical gadolinium deposition.