An unprecedented amount of parallel synthesis information was accumulated within Pfizer over the past 12 years. This information was captured by an informatics tool known as PGVL (Pfizer Global Virtual Library). PGVL was used for many aspects of drug discovery including automated reactant mining and reaction product formation to build a synthetically feasible virtual compound collection. In this report, PGVL is discussed in detail. The chemistry information within PGVL has been used to extract synthesis and design information using an intuitive desktop Graphic User Interface, PGVL Hub. Several real-case examples of PGVL are also presented.

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Usually, the surface quality of components produced under turning of particle reinforced metal matrix composites (PRMMCs) is one of the most important factors influencing their practical performance. Keeping good surface quality needs additional manufacturing cost or loss of productivity. In this study, semi-finish turning tests were conducted using high-power diode laser and cemented carbide tools to evaluate the superiority of the laser-assisted machining of PRMMCs and better understand its governing mechanism. The Taguchi method is used to optimize the cutting parameters in laser-assisted machining (LAM) by seeking the smallest surface roughness and the best signal-to-noise ratio. The results of orthogonal experiment revealed that the most significant turning parameter for surface roughness was feed rate, followed by the rotational speed, the cutting temperature, and the depth of cut. LAM provides a larger material removal rates under the same surface roughness compared with conventional machining. The tool wear mechanism for coated and uncoated cemented carbide tools was evaluated, and the LAM provides a maximum 2.31 times improvement in cemented carbide tools over conventional machining. Additionally, an economic analysis reveals significant benefits of diode laserassisted machining of PRMMCs over conventional machining with conventional carbide tools.

Laser-assisted machining (LAM) offers the ability to machine superalloys more efficiently and economically by providing the local heating of the workpiece prior to material removed by traditional cutting tool. The effectiveness of LAM was studied by measuring the cutting forces, surface roughness, and tool wear under various material removal temperatures (Tmr). It is demonstrated by an appropriate 30-70 % decrease in cutting force, an obvious reduction in the surface roughness, and an appropriate 46 % increase in coated tool life over conventional machining (CM). Machining experiments are then carried out to evaluate the wear behavior of different commercially available coated tools (TiCN, TiAlN, Ti(CN)/ Al 2 O 3 /TiN). These coatings were selected since they have the capability to withstand the temperatures experienced in LAM. The results of laser-assisted milling experiments indicate that abrasive and adhesive wear were the dominant wear mechanisms, controlling the deterioration of the carbide tools. The TiAlN-coated tools exhibited the highest wear resistance at normal cutting speeds of 30 m/min. The triple layer CVD coated tool failure mode was non-uniform flank wear due to the adhesion and depth-of-cut notching. TiCN performed poorly due to their inferior adhesion characteristics with the base material. The main failure mode for TiCN was nonuniform flank wear and chipping, and also, a significant notch was observed. Sub-surface quality has been evaluated by observing the microstructure of cross sections and measuring the micro-hardness.

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