No abstract

MYC+/BCL-2+ patients have worse chemotherapy response and poorer prognosis than patients who only express one of the two proteins, suggesting that assessment of MYC and BCL-2 expression by immunohistochemistry has clinical significance in predicting clinical outcomes of PGI-DLBCL patients.

The temperature-dependent deformation and damage behaviors of ultrafine-grained (UFG) Cu and Ti produced by equal channel angular pressing (ECAP) were investigated and compared. It was found that ECAPed materials with different crystalline structures, e.g. the present fcc Cu and hcp Ti, exhibited significantly distinctive high-temperature deformation and damage characteristics. As the testing temperature is below recrystallization, small- and large-scale cracks or voids formed along the shear bands (SBs) on the surface of UFG Cu, whereas only a few fine shear lines and some non-propagation voids appeared on the surface of UFG Ti. As the temperature is above recrystallization, some small cracks (or voids) formed along grain boundaries and slip deformation took place in many coarsened grains, while only extrusions and intrusions instead of obvious cracks or voids are observable for UFG Ti. The corresponding microstructual changes after compressive deformation, e.g. grain coarsening, were also examined and confirmed by TEM observations.

(HAp/SiO2)/Ti biocomposites were prepared by the powder metallurgy method. The phase compositions and the in vitro bioactivity of such biocomposites were systematically characterized. The XRD result shows that the phase compositions of (HAp/SiO2)/Ti composites are mainly composed of Ca4O(PO4)2 (TTCP), Ti, TiO2 and CaO. The synthesized (HAp/SiO2)/Ti biocomposites exhibit a good bioactivity, for example, after the samples are immersed in SBF solution only for 24 hours, the bone-like layer consisting of spherical apatite crystal clusters has deposited on the surface of the samples. The density and thickness of the apatite layer increases with increasing immersion time. The formation process and mechanisms of bone-like apatite layer are also discussed.

Magnesium has been recently recognized as a biodegradable metal for bone substitute applications. In the present work, a novel magnesium based scaffold with a specific two-layer structure was prepared for powder metallurgical process. The outer layer of the scaffold shows an interconnected porous structure, so that the fresh fluid can be easily sent into the material, allowing the ingrowth of new bone tissue. The inner compact structure reinforced by the salt particles can increase the strength of the material. Structural characterizations and mechanical tests of the materials demonstrate that the structural and mechanical properties of the magnesium-based scaffold with an appropriate salt content prepared by the current method are quite comparable to those of cancellous bone. Therefore, the magnesium-based scaffold with such a two-layer structure has the potential to serve as degradable implants for bone substitute applications.