The coastal or sea‐crossing bridges located in seismic regions are experiencing long‐term chloride‐induced corrosion in their life cycles and have a high risk of suffering from strong earthquakes. Thus, the fragilities of these bridges must be properly evaluated under the multiple hazards of corrosion and earthquake. Conventional fragility assessment requires expensive computational efforts despite extensive applications in previous research. To this end, this paper proposes a life‐cycle fragility analysis framework based on the endurance time method to investigate the deterioration impact on the seismic fragility of bridges. An example sea‐crossing cable‐stayed bridge is utilized as a case study and modeled by OpenSees considering different service years. The life‐cycle fragility curves of the example bridge are generated using the artificial endurance time series. Fragility analysis results show that the proposed method is capable of assessing the life‐cycle seismic fragility of the bridge with high efficiency. The bearing shows a higher damage probability than the pylon and pier. As the service time increases, the structural deterioration has a marginal impact on the system fragility of the bridge, while the component fragility varies across different components. The structural deterioration results in beneficial effects on the pylon and the bearing at the pylon but exerts adverse effects on the pier and the bearing at the pier.
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