Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) is reported, in which the rim of commercially available IOLs (C-IOLs) is decorated with silica coated Au nanorods (Au@SiO ), for high-efficient prevention of PCO after cataract surgery. The Nano-IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano-IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano-IOLs shows good biocompatibility as well as extraordinary region-confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%-40% by using Nano-IOLs, which is significantly lower than the control group that treated with C-IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO-induced loss of vision.

A novel copolymer network was successfully prepared by combining the reversible addition–fragmentation chain-transfer polymerization (RAFT) and addition reaction between hydroxyl and vinyloxy groups. 2-Hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) were copolymerized in 1,4-dioxane with 2,2′-azobisisobutyronitrile as initiator and 2-(ethoxycarbonyl)prop-2-yl dithiobenzoate as a RAFT agent. The molecular weight of poly(HEMA-co-MMA) was well controlled and the polydispersity was low. The hydroxyl group from the HEMA unit in the copolymer underwent an addition reaction with 1,4-cyclohexanedimethanol divinyl ether in the presence of pyridinium p-toluenesulfonate, generating a copolymer network with an acetal component in the crosslinking segment. The crosslinking time depended on the molar ratio of HEMA and MMA in the poly(HEMA-co-MMA). After being treated in strong acid, the copolymer network was able to be degraded owing to the acetal structure, but the backbone chains of poly(HEMA-co-MMA) remained intact.

Mucopolysaccharidosis type II (Hunter syndrome) is a lysosomal storage disease caused by a deficiency of iduronate‐2‐sulfatase. Most reported patients are males because of X‐linked recessive inheritance pattern. Only a few female patients with Hunter syndrome have been reported, and there is no prior report of offspring from a patient with Hunter syndrome. In this report, we describe a woman with mild manifestations of Hunter syndrome who gave birth to a daughter. Both the mother and daughter carried the p.R443X mutation in exon 9 of the ID2S gene. Iduronate‐2‐sulfatase activity in the mother was as low as that found in male Hunter syndrome patients, but it was in the low‐normal range in her daughter. Unlike her mother, the daughter did not show any physical signs of Hunter syndrome, and urinary excretion of glycosaminoglycan was within normal range. However, she had severe pulmonary vein stenosis with pulmonary hypertension and a large atrial septal defect and died at 11 months of age. © 2010 Wiley‐Liss, Inc.

A novel copolymer network with acetal structure was prepared using bis [4-(vinyloxy)butyl] (4-methyl-1,3-phenylene)biscarbamate (BECT) as the crosslinking agent. Firstly, a tri-copolymer of maleic anhydride (MAn), n-butyl vinyl ether (BVE) and 4-hydroxybutyl vinyl ether (HBVE) was synthesized via free-radical polymerization with 2,2′-azobisisobutyronitrile as the initiator. The tri-copolymer consisted of two sorts of alternating units, MAn-alt-BVE and MAn-alt-HBVE. The linear copolymer Poly((MAn-alt-BVE)-co-(MAn-alt-HBVE)) with pending hydroxyl groups was then combined with BECT in the presence of pyridinium p-toluenesulfonate, generating a copolymer network comprising acetal components in the crosslinking segment. This polymer network exhibited degradation in acid conditions.