Virtual reality (VR) learning is still a new challenge in the e-learning domain.This paper is one of the early studies bringing forward the concept of learning 5S principles (a core technique in Industrial Engineering) using VR and performed an exploratory qualitative study in an undergraduate course to discover factors that would facilitate or hinder students from accepting this idea -learning 5S principles using VR. Four factors and 14 subfactors were identified based on 47 valid responses. They were human attributes, human-machine interaction, technology characteristics, and training contents. The results should help teachers, schools, VR device manufacturers to understand the benefits and challenges of teaching 5S principles using VR.