Postpartum depression (PPD), a severe mental health disorder, is closely associated with decreased gonadal hormone levels during the postpartum period. Mangiferin (MGF) possesses a wide range of pharmacological activities, including anti-inflammation. Growing evidence has suggested that neuroinflammation is involved in the development of depression. However, the role of MGF in the development of PPD is largely unknown. In the present study, by establishing a hormone-simulated pregnancy PPD mouse model, we found that the administration of MGF significantly alleviated PPD-like behaviors. Mechanistically, MGF treatment inhibited microglial activation and neuroinflammation. Moreover, we found that MGF treatment inhibited mitogen-activated protein kinase (MAPK) signaling in vivo and in vitro. Together, these results highlight an important role of MGF in microglial activation and thus give insights into the potential therapeutic strategy for PPD treatment.

The paper presents a new type of wire rope safety barrier, which has many posts with C-shaped cross section and 5 ropes, by way of designing the shape of the post, the diameter of the rope, the arrangement and the number of ropes etc., on the basis of the form of structure of the most advanced foreign existing wire rope safety barrier -BRIFEN. And in order to realize that the barrier is designed as A class protective flexible safety fence, a series of finite element models are established, taking the thickness of the steel plate of C-post. After simulation experiment, discussion and analysis, the relation of the maximum dynamic deformation and the thickness of C-post is gotten. The research shows that the flexural strength of C-post increases and the corresponding maximum dynamic deformation decreases with the thickness of Cpost increases, which providing an important reference for subsequent research and Vehicle Crash Test.