We fabricated a hybrid on-chip acousto-electric (AE) and field-effect device to investigate the modulation of acoustic carrier transportation by gate voltage. The device fabrication exploited a surface micromachining aluminum nitride process on a silicon wafer, facilitating an integration of a surface acoustic wave (SAW) delay line and a graphene field-effect transistor. The SAW device induced an AE current in graphene, which scales linearly with the input power and remains essentially constant when subtracting the offset current at different DC biases. At a constant DC bias, the AE current can be modulated by the gate voltage, due to the change of the carrier mobility in graphene. A four-fold enhancement in the AE current was realized when ∼35 V voltage was applied to the gate electrode. The highly integrated device proves to be a powerful tool to understand the AE current in graphene, and since it supports integration for versatile functionality, it opens an avenue to explore the properties of diverse nanomaterials.

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This paper reports an uncooled infrared (IR) detector based on a micromachined piezoelectric resonator operating in resonant and resistive dual-modes. The two sensing modes achieved IR responsivities of 2.5 Hz/nW and 900 μdB/nW, respectively. Compared with the single mode operation, the dual-mode measurement improves the limit of detection by two orders of magnitude and meanwhile maintains high linearity and responsivity in a higher IR intensity range. A combination of the two sensing modes compensates for its own shortcomings and provides a much larger dynamic range, and thus, a wider application field of the proposed detector is realized.

Tremendous amount of whole-genome sequencing data have been provided by large consortium projects such as TCGA (The Cancer Genome Atlas), COSMIC and so on, which creates incredible opportunities for functional gene research and cancer associated mechanism uncovering. While the existing web servers are valuable and widely used, many whole genome analysis functions urgently needed by experimental biologists are still not adequately addressed. A cloud-based platform, named CG (ClickGene), therefore, was developed for DIY analyzing of user’s private in-house data or public genome data without any requirement of software installation or system configuration. CG platform provides key interactive and customized functions including Bee-swarm plot, linear regression analyses, Mountain plot, Directional Manhattan plot, Deflection plot and Volcano plot. Using these tools, global profiling or individual gene distributions for expression and copy number variation (CNV) analyses can be generated by only mouse button clicking. The easy accessibility of such comprehensive pan-cancer genome analysis greatly facilitates data mining in wide research areas, such as therapeutic discovery process. Therefore, it fills in the gaps between big cancer genomics data and the delivery of integrated knowledge to end-users, thus helping unleash the value of the current data resources. More importantly, unlike other R-based web platforms, Dubbo, a cloud distributed service governance framework for ‘big data’ stream global transferring, was used to develop CG platform. After being developed, CG is run on an independent cloud-server, which ensures its steady global accessibility. More than 2 years running history of CG proved that advanced plots for hundreds of whole-genome data can be created through it within seconds by end-users anytime and anywhere. CG is available at http://www.clickgenome.org/ . Electronic supplementary material The online version of this article (10.1186/s13040-019-0202-3) contains supplementary material, which is available to authorized users.

Acceleration sensor is usually used to test the performance of equipment under high-acceleration vibration. It is widely used in aero-engine, steam turbine and other equipment working in high-acceleration vibration environment. Calibration is an important means to ensure the accuracy and reliability of the measurement results of the acceleration sensor. Aiming at the conventional intermediate frequency (IF) calibration system using many instruments and complicated operation, this paper designs a resonant high-acceleration calibration system based resonant beam. First, the system amplifies the acceleration amplitude through the resonance of the resonant beam at the natural frequency, thereby generating high-acceleration values to calibrate the sensor. Then the vibration control algorithm of the calibration system is optimized, and the stability of the system is verified through experiments. Finally, the communication between the upper and lower computers is carried out in the vibration control system and the laser measurement system, and the metrological traceability is realized. The experimental results show that the system can effectively calibrate the sensitivity amplitude and phase of high-acceleration sensor in the frequency range of 100-2148 Hz and the acceleration range of 50-11 853 m s −2 . This calibration system is of great significance to the research on the calibration of IF acceleration sensor.