ObjectiveMedication adherence plays a key role in type 2 diabetes (T2D) care. Identifying patients with high risks of non-compliance helps individualized management, especially for China, where medical resources are relatively insufficient. However, models with good predictive capabilities have not been studied. This study aims to assess multiple machine learning algorithms and screen out a model that can be used to predict patients’ non-adherence risks.MethodsA real-world registration study was conducted at Sichuan Provincial People’s Hospital from 1 April 2018 to 30 March 2019. Data of patients with T2D on demographics, disease and treatment, diet and exercise, mental status, and treatment adherence were obtained by face-to-face questionnaires. The medication possession ratio was used to evaluate patients’ medication adherence status. Fourteen machine learning algorithms were applied for modeling, including Bayesian network, Neural Net, support vector machine, and so on, and balanced sampling, data imputation, binning, and methods of feature selection were evaluated by the area under the receiver operating characteristic curve (AUC). We use two-way cross-validation to ensure the accuracy of model evaluation, and we performed a posteriori test on the sample size based on the trend of AUC as the sample size increase.ResultsA total of 401 patients out of 630 candidates were investigated, of which 85 were evaluated as poor adherence (21.20%). A total of 16 variables were selected as potential variables for modeling, and 300 models were built based on 30 machine learning algorithms. Among these algorithms, the AUC of the best capable one was 0.866±0.082. Imputing, oversampling and larger sample size will help improve predictive ability.ConclusionsAn accurate and sensitive adherence prediction model based on real-world registration data was established after evaluating data filling, balanced sampling, and so on, which may provide a technical tool for individualized diabetes care.

Based on its proprietary thick‐dielectric electroluminescent (TDEL) display technology, iFire, together with joint development partners Sanyo and Dai Nippon Printing (DNP), has successfully developed 17‐inch full‐color prototypes with video quality comparable to CRT displays and a luminance of 300 cd/m2. The company's development of the Color‐By‐Blue (CBB) technique has further simplified the already simple manufacturing process of TDEL displays, and also accelerated iFire's development of the world's first full‐color 34‐inch inorganic electroluminescent HDTV screen. Based on detailed cost model analysis, iFire believes that the TDEL technology can be used to achieve high performance and low cost HDTV displays, and is initially targeting the 30″ – 40″ market segment, with commercial production planned for the 2006 timeframe.

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