: Restless legs syndrome (RLS)/Willis-Ekbom disease is a neurologic disorder characterized by a strong desire to move when at rest (usually in the evening) and paraesthesia in their lower legs. The most widely used therapies for first-line treatment of RLS are dopaminergic drugs; however, their long-term use can lead to augmentation. α2δ Ligands, opioids, iron, glutamatergic drugs, adenosine, and sleep aids have been investigated as alternatives. The pathogenesis of RLS is not well understood. Despite the efficacy of dopaminergic drugs in the treatment of this disorder, unlike in Parkinson’s disease dopaminergic cell loss in the substantia nigra has not been observed in RLS. The etiology of RLS is likely complex, involving multiple neural pathways. RLS-related genes identified in genome-wide association studies can provide insight into the mechanistic basis and pathophysiology of RLS. Here we review the current treatments and knowledge of the mechanisms underlying RLS.

Objective Anxiety is thought to be a common symptom in patient s who suffer from acute coronary syndrome (ACS). This study aims to present a general data about the anxiety symptoms in Chinese ACS patients, and evaluate the impact of anxiety symptoms on their quality of life (QOL). Method We enrolled 454 Chinese patient s with ACS from ShangHai, whose baseline data were obtained within 1 week after hospital admission. The subscale of Chinese version of the Hospital Anxiety and Depression Scale (HADS-A) and SF-36 were used to assess anxiety and their QOL, respectively. All the participant s were divided into 2 main groups: HADa $6 (n¼247) and HADa 0.05). The participants from non-anxiety group had a better QOL than anxiety group (p<0.01). And anxiety was negatively associated with the QOL (p<0.01). Logistic regression analysis didn't suggest inflammatory factor is an important risk factor for anxiety of ACS patients. Conclusion The study confirmed the western notion that anxiety is a common psychosocial problem, which also applies to Chinese patient s diagnosed with ACS. Anxious ACS patients have rather worse quality of life. e0284 INTRAVASCULAR ULTRASOUND (IVUS) CHARACTERISTICS

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Objective Anxiety is thought to be a common symptom in patient s who suffer from acute coronary syndrome (ACS). This study aims to present a general data about the anxiety symptoms in Chinese ACS patients, and evaluate the impact of anxiety symptoms on their quality of life (QOL). Method We enrolled 454 Chinese patient s with ACS from ShangHai, whose baseline data were obtained within 1 week after hospital admission. The subscale of Chinese version of the Hospital Anxiety and Depression Scale (HADS-A) and SF-36 were used to assess anxiety and their QOL, respectively. All the participant s were divided into 2 main groups: HADa $6 (n¼247) and HADa 0.05). The participants from non-anxiety group had a better QOL than anxiety group (p<0.01). And anxiety was negatively associated with the QOL (p<0.01). Logistic regression analysis didn't suggest inflammatory factor is an important risk factor for anxiety of ACS patients. Conclusion The study confirmed the western notion that anxiety is a common psychosocial problem, which also applies to Chinese patient s diagnosed with ACS. Anxious ACS patients have rather worse quality of life. e0284 INTRAVASCULAR ULTRASOUND (IVUS) CHARACTERISTICS