The research object of this paper is single-phase PWM rectifier, the purpose is to reduce the total harmonic distortion (THD) of the grid-side current. A model predictive current control (MPCC) with fixed switching frequency and dead-time compensation is proposed. First, a combination of an effective vector and two zero vectors is used to fix the switching frequency, and a current prediction equation based on the effective vector’s optimal action time is derived. The optimal action time is resolved from the cost function. Furthermore, in order to perfect the established prediction model and suppress the current waveform distortion as a consequence of the dead-time effect, the dead-time’s influence on the switching vector’s action time is analyzed, and the current prediction equation is revised. According to the experimental results, the conclusion is that, firstly, compared with finite-control-set model predictive control, proportional-integral-based instantaneous current control (PI-ICC) scheme and model predictive direct power control (MP-DPC), the proposed MPCC has the lowest current THD. In addition, the proposed MPCC has a shorter execution time than MP-DPC and has fewer adjusted parameters than PI-ICC. In addition, the dead-time compensation scheme successfully suppresses the zero-current clamping effects, and reduce the current THD.

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Bone immunity regulates osteoclast differentiation and bone resorption and is a potential target for the treatment of postmenopausal osteoporosis (PMOP). The molecular network between bone metabolism and the immune system is complex. However, the molecular mechanism underlying the involvement of the major histocompatibility complex class II (MHC-II) molecule protein presentation pathway in PMOP remains to be elucidated. The MHC-II molecule is a core molecule of the protein presentation pathway. It is combined with the processed short peptide and presented to T lymphocytes, thereby activating them to become effector T cells. T-cell-derived inflammatory factors promote bone remodeling in PMOP. Moreover, the MHC-II molecule is highly expressed in osteoclast precursors. MHC-II transactivator (CIITA) is the main regulator of MHC-II gene expression and the switch for protein presentation. CIITA is also a major regulator of osteoclast differentiation and bone homeostasis. Therefore, we hypothesized that the MHC-II promotes osteoclast differentiation, providing a novel pathogenic mechanism and a potential target for the treatment of PMOP.

This paper presents a three‐vector model predictive power control with neutral‐point voltage balance (TVMPPC‐NPVB) and a dead‐beat control for three‐phase three‐level T‐type rectifier. Three vectors are adopted to reduce the current ripple, balance the neutral‐point voltage and achieve unity power factor on the AC side simultaneously, while the conventional model predictive power control suffers from large current ripple, difficulty in designing the weighting factor and computational burden. In the proposed strategy, two cost functions are derived to select the optimal space vector sequence and reduce the computational burden. The action time of each vector is introduced in detail. The traditional PWM rectifier utilizes PI controller to regulate the output voltage. But PI controller tends to have a long transition time and big variation on output voltage when the load changes suddenly. The proposed dead‐beat control is capable of solving these problems caused by conventional PI controller. Both simulation and experimental results are shown to confirm the effectiveness of the proposed method.

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