Abstract-This paper develops a model that addresses sentence embedding, a hot topic in current natural language processing research, using recurrent neural networks (RNN) with Long Short-Term Memory (LSTM) cells. The proposed LSTM-RNN model sequentially takes each word in a sentence, extracts its information, and embeds it into a semantic vector. Due to its ability to capture long term memory, the LSTM-RNN accumulates increasingly richer information as it goes through the sentence, and when it reaches the last word, the hidden layer of the network provides a semantic representation of the whole sentence. In this paper, the LSTM-RNN is trained in a weakly supervised manner on user click-through data logged by a commercial web search engine. Visualization and analysis are performed to understand how the embedding process works. The model is found to automatically attenuate the unimportant words and detects the salient keywords in the sentence. Furthermore, these detected keywords are found to automatically activate different cells of the LSTM-RNN, where words belonging to a similar topic activate the same cell. As a semantic representation of the sentence, the embedding vector can be used in many different applications. These automatic keyword detection and topic allocation abilities enabled by the LSTM-RNN allow the network to perform document retrieval, a difficult language processing task, where the similarity between the query and documents can be measured by the distance between their corresponding sentence embedding vectors computed by the LSTM-RNN. On a web search task, the LSTM-RNN embedding is shown to significantly outperform several existing state of the art methods. We emphasize that the proposed model generates sentence embedding vectors that are specially useful for web document retrieval tasks. A comparison with a well known general sentence embedding method, the Paragraph Vector, is performed. The results show that the proposed method in this paper significantly outperforms it for web document retrieval task.

We propose a system that determines the salience of entities within web documents. Many recent advances in commercial search engines leverage the identification of entities in web pages. However, for many pages, only a small subset of entities are central to the document, which can lead to degraded relevance for entity triggered experiences. We address this problem by devising a system that scores each entity on a web page according to its centrality to the page content. We propose salience classification functions that incorporate various cues from document content, web search logs, and a large web graph. To cost-effectively train the models, we introduce a soft labeling methodology that generates a set of annotations based on user behaviors observed in web search logs. We evaluate several variations of our model via a large-scale empirical study conducted over a test set, which we release publicly to the research community. We demonstrate that our methods significantly outperform competitive baselines and the previous state of the art, while keeping the human annotation cost to a minimum.

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Long noncoding RNAs (lncRNAs), which are pervasively transcribed in the genome, are emerging in molecular biology as crucial regulators of cancer. RNA-seq data were downloaded from GEO of NCBI and further analyzed to identify novel targets in intrahepatic cholangiocarcinoma (iCCA). We investigated differences in lncRNA and mRNA profiles between 7 pairs of iCCA and adjacent normal tissues. 230 lncRNAs were differentially expressed more than four-fold change in iCCA tissues. Among these, 97 were upregulated and 133 downregulated relatively to normal tissues. Moreover, 169 lncRNAs and 597 mRNAs formed the lncRNA-mRNA co-expression network which consist 766 network nodes and 769 connection edges. Bioinformatics analysis identified these dysregulated lncRNAs were associated with cholesterol homeostasis, insoluble fraction and lipid binding activity and were enriched in complement and coagulation cascades and PPAR signaling pathway. These results uncovered the landscape of iCCA-associated lncRNAs and co-expression network, providing insightful information about dysregulated lncRNAs in iCCA.

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