a b s t r a c tA large volume of fracturing fluid is pumped into a well to stimulate shale formation. The water is imbibed into the reservoir during this procedure. The effect of the imbibed water on gas recovery is still in debate. In this work, we study the spontaneous imbibition of water into marine shale samples from the Sichuan Basin and continental shale samples from Erdos Basin to explore the fluid imbibition characteristics and permeability change during water imbibition.Comparison of imbibition experiments shows that shale has stronger water imbibition and diffusion capacity than relatively higher permeability sandstone. Once the imbibition stops, water in shale has stronger ability to diffuse into deeper matrix, the water content in the main flow path decreases.Experiments in this study show that marine shale has stronger water imbibition capacity than continental shale. The permeability of continental shale decreases significantly with increasing imbibition water volume; however, the permeability of marine shale decreases at first and increases after a certain imbibition time. The induced fracture is obvious in the marine shale. SEM analysis shows that the relationship between the clay mineral and organic matter of continental shale is much more complex than that of marine shale, which may be the key factor restricting the water imbibition because the flow path is trapped by swelled clay minerals.Through this study, we concluded that whether gas recovery benefits from water imbibition depends on three aspects: 1) the diffusion ability of liquid into matrix; 2) the new cracks introduced by imbibed water; and 3) the formation sensibility. This study is useful for optimizing fracture fluids and determining the best flow-back method.

Large volume water filtrates into the shale formation during multi-stage fracturing. The influence of water imbibition to shale permeability, which still needs further investigation, is crucial to gas production. This paper presents a series of experiments to investigate the shale permeability change during water imbibition in comparison to typical sandstone and volcanic samples using the pulse-decay permeability technique. The permeability greatly fluctuates with the water imbibed into the shale, which is far different from that of sandstone and volcanic rock. Factors such as water blocking, stress sensitivity, and clay swelling are discussed. Five typical permeability changes are put forward, which are conducive to understand the effect of water imbibition on gas flow post-fracturing. The work indicates that the shale permeability enhancement by water imbibition may be one of the reasons of obtaining shale gas well productivity to increase by soaking after fracturing. The results and conclusions are fundamentally important to guide the industry practice, especially for the determination of the soaking time after fracturing in a shale gas reservoir.

Methacrylated gelatin (GelMA)/bacterial cellulose (BC) composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed by photo-crosslinking. The morphology of GelMA/BC hydrogel was examined by scanning electron microscopy and compared with pure GelMA. The hydrogels had very well interconnected porous network structure, and the pore size decreased from 200 to 10 µm with the increase of BC content. The composite hydrogels were also characterized by swelling experiment, X-ray diffraction, thermogravimetric analysis, rheology experiment and compressive test. The composite hydrogels showed significantly improved mechanical properties compared with pure GelMA. In addition, the biocompatility of composite hydrogels were preliminarily evaluated using human articular chondrocytes. The cells encapsulated within the composite hydrogels for 7 days proliferated and maintained the chondrocytic phenotype. Thus, the GelMA/BC composite hydrogels might be useful for cartilage tissue engineering.

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BackgroundVenous thromboembolism (VTE) is considered a potentially serious complication of knee arthroscopy and leads to conditions such as deep venous thrombosis (DVT) and pulmonary embolism (PE). Low-molecular-weight heparin (LMWH) is widely employed in knee arthroscopy to reduce perioperative thromboembolic complications. However, the efficacy and safety of LMWH in knee arthroscopy remains unclear.MethodsSeven randomized controlled clinical trials on LMWH in knee arthroscopy were identified and included in this meta-analysis. The main outcomes of the effectiveness (prevention of DVT and PE) and complications (death, major bleeding, and minor bleeding) of LMWH in knee arthroscopic surgery were assessed using Review Manager 5.3 software.ResultsThe meta-analysis indicated that LMWH prophylaxis comprised 79% of asymptomatic DVT. No association was found in symptomatic VTE (RR: 0.90; 95% confidence interval [CI]: 0.39–2.08; P = 0.80), symptomatic DVT (RR: 0.79; 95% CI: 0.28–2.23; P = 0.66), symptomatic PE (RR: 1.36; 95% CI: 0.37–4.97; P = 0.64) and major bleeding (RR: 0.70; 95% CI: 0.12–3.95; P = 0.68) risk during LMWH prophylaxis were identified. Death was not reported in these studies. Moreover, there was a lower incidence of minor bleeding (RR: 0.64; 95% CI: 0.49 to 0.83; P = 0.001) in the control group than in the LMWH group.ConclusionCompared with the control group, the group treated with LMWH after knee arthroscopy was no association in reducing the symptomatic VTE rate, symptomatic DVT rate or symptomatic PE rate. The symptomatic VTE rate was 0.5% (11/2,166) in the LMWH group versus 0.6% (10/1,713) in the control group. Although the limitations of this meta-analysis cannot be ignored, the results of our study show that LMWH after knee arthroscopy is ineffective. We recommend that LMWH should not be routinely provided for knee arthroscopy.Trial registrationClinicalTrials.gov NCT03164746