around 3-6 months. [4] It is exciting that certain new therapies that are safe and efficient with little side effects have been developed in recent years, such as gene therapy, [5] photothermal therapy, [6] photodynamic therapy, [7] and so on. Of course, synergistic therapy should be more effective due to not only the accumulation of therapeutic effects, but also the mutual promotion of different treatments. [8] However, the check point in the collaborative treatment is the synthesis of multifunctional materials. [9] Among various types of nanomaterials, graphene oxide (GO) has exhibited a great potential in biomedicine. GO has large surface area for multifarious therapeutic agents, and the hydroxyl and carboxyl groups on its surface, making it more dispersible and easier to be functionalized. [10] More importantly, the absorption in the near infrared (NIR) determines its excellent photothermal capability. In recent years, in order to further improve the photothermal performance and entitle materials imaging function to more accurately treat diseases, composite nanomaterials have attracted extensive attentions. [5c,11] Gold nanoparticles with tunable shape and size have been reported to hybridize with other materials for better therapeutic effects. [12] Among them, gold nanostars (AuNS) could be a more suitable option for hybridization with GO to achieve a higher Nanomaterial-based pancreatic cancer treatment has received widespread attention and rapid development in the past few years. The major challenges include the poor combination of diagnosis and therapy, the difficulty in targeting therapy from the root and the unsatisfactory antitumor efficiency, which is accompanied by a great risk of relapse and metastasis. In this work, a positively charged lipid bilayer membrane is coated on reduced graphene oxide@gold nanostar (rGO@AuNS) for photoacoustic/photothermal dual-modal imaging-guided gene/photothermal synergistic therapy of pancreatic cancer. In addition, the cross-linking of folic acid on the surface of rGO@AuNS-lipid can specifically bind after recognizing folic acid receptors on the surface of cancer cells, and greatly improve the targeting ability of the nanomaterial and the performance of imaging diagnosis by receptormediated endocytosis. Moreover, the photothermal and gene (targeting G12V mutant K-Ras gene) synergistic therapy shows outstanding anticancer efficacy for pancreatic cancer tumor bearing mice, and it is noteworthy that the treatment groups have anti-liver metastasis of pancreatic cancer. The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.202003707. Despite the great advances in diagnostic tools and medical level in the past decades, cancer remains to be one of the scariest diseases in the 21st century. [1] Among all kinds of cancers, pancreatic cancer with poor prognosis is responsible for one fourth of the deaths worldwide, with the 5-year survival rate around 4-7%. [2] Traditionally, the main treatments for cancer include ...
