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On the basis of the structural characteristics of subway stations, structural inertial force can be simplified as multiple concentrated force acting on the member connecting node by using equivalent inertial force method of seismic calculation in soft site, and then internal forces of the structure will be analyzed. According to the principle that the maximum bending moment values of equivalent inertial force method and dynamic time-history analysis method are equal and the location is the same, the value of equivalent inertial force is determined, and the shear and axial force are ensured by introducing correction factor. The result shows that the calculation results of equivalent inertial force method are accurate and reliable. It can meet the design requirements and improve computational efficiency.