ABSTRACT. The critical role of ATP-binding cassette B1 (ABCB1) in the function of the blood-brain barrier led us to conducted this prospective study in order to investigate the clinical outcome of patients suffering from severe traumatic brain injury. A total of 182 patients with traumatic brain injury were included in our study. Genotyping of ABCB1 C3435T and G2677T/A was conducted using polymerase chain reaction-restriction fragment length polymorphism. Using multivariatelogistic regression analysis, we found that patients carrying the CT+CC genotype of ABCB1 C3435T were more likely to have a better neurological outcome when compared with the TT genotype (odds ratio = 2.71, 95% confidence interval = 1.12-6.86). However, no significant association was found between the G2677T/A polymorphism and outcome of traumatic brain injury patients. Our study provides important information regarding the prognostic value of ABCB1 C3435T, and the ABCB1 C3435T polymorphism may be used as a predictive marker for the outcome of traumatic brain injury patients.

The chaotic synchronization in n-dimensional large map networks with local coupling and their size stabilities in the node number N-->infinity are studied analytically and numerically. The analytical results show that the chaotic synchronization is stable for N-->infinity in the presence of the external driving or global coupling. The numerical calculations show that, as the driving or global interaction strength increases from zero, the network states have the whole route: spatiotemporal chaotic state --> cluster chaotic synchronous state --> complete chaotic synchronous state --> spatiotemporal pattern --> spatiotemporal chaotic state.