In our experience patients undergoing circumcision are mostly concerned about pain and penile appearances. We conducted a prospective randomized trial to assess the benefits of a new disposable circumcision suture device (DCSD). A total of 942 patients were equally divided into three groups (conventional circumcision, Shang ring and disposable suture device group). Patients in the DCSD group were anesthetized with compound 5% lidocaine cream, the others with a 2% lidocaine penile block. Operation time, intra-operative blood loss, incision healing time, intra-operative and post-operative pain, the penile appearance and overall satisfaction degree were measured. Operation time and intra-operative blood loss were significantly lower in the Shang ring and suture device groups compared to the conventional group (P < 0.001). Intra-operative pain was less in the suture device group compared with the other two groups (P < 0.001); whereas post-operative pain was higher in the conventional group compared to the other two groups (P < 0.001). Patients in the suture device (80.57%) and Shang ring (73.57%) groups were more satisfied with penile appearances compared with the conventional circumcision group (20.06%, P < 0.05). Patients in suture device group also healed markedly faster than the conventional group (P < 0.01). The overall satisfaction rate was better in the suture device group (78.66%) compared with the conventional (47.13%) and Shang ring (50.00%) groups (P < 0.05). The combination of DCSD and lidocaine cream resulted in shorter operation and incision healing times, reduced intra-operative and post-operative pain and improved patient satisfaction with the cosmetic appearances.

Egg intake has been hypothesized to promote carcinogenesis due to its potential to increase circulating levels of cholesterol. Epidemiological findings regarding the association between egg consumption and risk of bladder cancer have been inconsistent. We performed a meta-analysis of the available data. Relevant studies were identified by a PubMed database search of articles dating from between January 1980 and December 2011. We identified 4 cohort and 9 case-control studies of egg intake and risk of bladder cancer. Both fixed- and random-effects models were used to calculate the summary risk estimates (REs). The combined RE of bladder cancer for the highest compared with the lowest egg intake was 0.94 (95% CI, 0.69–1.18) and weak evidence of heterogeneity was observed. The association between egg intake and risk of bladder cancer differed significantly by geographic region, with a 28% reduced risk in Japanese. Our results provided no strong evidence of a significant association of egg consumption with bladder cancer incidence but showed a protective effect in Japanese.

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Penile squamous cell carcinoma has been commonly reported in the past decades. We describe a rare case of a huge squamous cell carcinoma of the penis in a 65-year-old patient with a 4-year history of tumor growth, for which total penectomy, perineal urethrostomy and bilateral inguinal lymphadenectomy were carried out. We suggest that aggressive surgical intervention should be recommended for those with well-differentiated penile carcinoma regardless of the size of the tumor.

Objective: Coreceptors are important for HIV-1 entry into target cells and disease progression. The impact of HIV-1 and highly active antiretroviral treatment (HAART) on coreceptor expression has been little studied. Methods: Expression of C-C chemokine receptor (CCR) 5 and C-X-C chemokine receptor (CXCR) 4 on CD4þ and CD8 þ T cells was compared in HIV-1-infected individuals who had/had not received HAART, and in healthy controls. Relationships between coreceptors and their chemokine ligands were studied. Results: This study included 23 controls and 88 HIV-1-infected individuals, 35 of whom were HAART naïve. Percentages of CCR5 and CXCR4þ CD8 þ T cells were higher, and CXCR4þ CD4 þ T cells were lower, in patients than in controls. Patients receiving HAART showed a higher percentage of CCR5 expression on CD4 þ T cells compared with HAART-naïve patients. HIVinfected individuals had significantly increased levels of peripheral ligands for coreceptors, compared with controls; levels were significantly higher in those receiving HAART compared with the HAART-naïve. Conclusions: HIV-1 infection increases coreceptor expression on T cells; HAART increases CCR5 expression further and decreases CXCR4 expression, reversing the switch from CCR5 to CXCR4, which was significant for CD4 þ T.