An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas is described. The protocol proceeds via domino double [4+2] annulations and features eco-benign catalyst & solvent,...

The multicomponent−multicatalyst reaction ((MC) 2 R) and visible-light catalysis have emerged as green and powerful strategies for achieving ideal syntheses. Here, we report the first example of a visible-light-induced approach toward spiroquinazolin(thi)ones. This (MC) 2 R features an eco-friendly energy source and solvent, metal-free catalysts, step-and atomeconomy, a relay catalysis strategy, air as green oxidant, mild conditions, and easily accessible starting materials.