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Coronary artery disease (CAD) has been one of main causes of heart diseases globally. The electrocardiogram (ECG) is a widely used diagnostic tool to monitor patients' heart activities, and medical personnel need to judge whether there are abnormal heartbeats according to captured results. Therefore, it is significant to identify ECG signals accurately and fast. In this paper, a fast and accurate electrocardiogram (ECG) classification system based on deep learning is proposed. In our model, stacked denoising autoencoders (SDAE), as encoder, automatically learns semantic encoding of heartbeats without any complex feature extraction in unsupervised way. Then bidirectional LSTM (Bi-LSTM) classifier achieves classification of heartbeats with semantic encoding. SDAE implements noise-reduction while Bi-LSTM takes full advantage of temporal information in data. At the same time, this method relieves impacts from unbalanced data by employing cost-sensitive loss function. We validate our model on MIT-BIH Arrhythmias Database, SVDB and NSTDB respectively. Compared with state-of-art methods, the final result verify that this newly proposed method not only has high accuracy but also boosts classifying efficiency. INDEX TERMS Arrythmia, bidirectional long short-term term network (Bi-LSTM), cost-sensitive learning, denoise, electrocardiogram (ECG), stacked denoising autoencoder (SDAE).

As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets.

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