Summary Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity. Here we reported that, glyburide, one of the FDA-approved drugs currently used to treat type 2 diabetes, can significantly enhance UCP1 expression in both brown and white adipocytes. Glyburide-fed mice exhibited a clear resistance to high-fat diet-induced obesity, reduced blood triglyceride level, and increased UCP1 expression in brown adipose tissue. Moreover, in situ injection of glyburide to inguinal white adipose tissue remarkably enhanced UCP1 expression and increased thermogenesis. Further mechanistic studies indicated that the glyburide effect in UCP1 expression in adipocytes was K ATP channel independent but may involve the regulation of the Ca 2+ -Calcineurin-NFAT signal pathway. Overall, our findings revealed the significant effects of glyburide in regulating UCP1 expression and thermogenesis in adipocytes, which can be potentially repurposed to treat obesity.

originates from the connective tissue of the periodontal ligament and the gingiva. Though Epulis is not a true tumor, as evidenced by its non-tumor biological characteristics and structure, it can easily relapse after resection (Beaumont et al., 2017;Chesterman et al., 2017). The pathogenesis of epulis has not yet been completely delineated. Previous studies have indicated that epulis can be caused by low-grade local irritation, traumatic injury, hormonal factors, and certain drugs (Kamal et al., 2012;Punde et al., 2013). Dental plaque(bacteria) plays an important role in all forms of epulis,

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