Aims: The goal of this study was to determine the relationship between leptin and thyroid profile in overweight/obese Manipur individuals. Materials and Methods: A total of 250 people (of either gender) between the ages of 20 and 65 were included in the study. The body mass index (BMI) was computed using the height and weight of the individual. Blood samples were used to assess serum leptin, thyroxine (T4), and thyroid stimulating hormone (TSH) levels. Significant variations between the groups were examined, as well as leptin and thyroid associations with various BMIs. Findings: Leptin levels were significantly higher in the overweight/obese group (12.73 ± 9.93 ng/ml) than in the control group (6.85 ± 6.49 ng/ml), (P <0.01). T4 levels did not differ significantly between normal (7.83 ± 1.51 µg/dl) and overweight/obese individuals (8.49 ± 2.00 µg/dl) whereas, TSH levels differed significantly between normal (2.79 ± 2.72 µIU/ml) and overweight/obese subjects (2.32 ± 1.54 µIU/ml), (P <0.05). A positive significant correlation was found between BMI and leptin (r = 0.38; P = 0.00) as well as between BMI and T4 (r = 0.14; P = 0.02). BMI and TSH did not have any correlations. Furthermore, there were no significant relationships between leptin and T4 or TSH.  Conclusion: The leptin and thyroid hormone are strongly linked in those who are overweight/obese.