The purpose of this study was to determine the influence of organizational learning and organizational stress on the performance of creative industry SMEs with the creativity of its owners/actors as mediator. Type of data used in this research was primary data, namely in the form of questionnaires and partly done also with interviews directly. Data analysis technique used was path analysis method. The population of this research was the owners of SMEs located in Palembang City under the guidance of the Ministry of Cooperatives and SMEs of South Sumatra Province based on data of 2016, which is classified as creative industry SMEs in the area of Palembang City as much as 65 SMEs. The sampling technique was census method. Based on that number, the returned questionnaires only 63 questionnaires from 65 questionnaires distributed. The results of research stated: first hypothesis is accepted where there is influence of learning organization on creativity of SMEs actors, with the influence of 0.705 (70.5%); second hypothesis is rejected, there is no influence of organizational stress on creativity of SMEs owners. Third hypothesis is accepted, where there is influence of learning organization on performance of creative industry SMEs, with the influence of 0.229 (22.9%). Fourth hypothesis is accepted, there is influence of organizational stress on performance of creative industry SMEs, with the influence of 0.229 (22.9%). Fifth hypothesis is accepted, where there is influence of creativity of SMEs owners on performance of creative industry SMEs, with the influence of 0.254 (25.4%). Sixth hypothesis is accepted, where there is influence of learning organization on performance of creative industry SMEs through creativity of SMEs owners as mediator variable with total effects of 0.589 or 58.9%. Seventh hypothesis is accepted, where is influence of organizational stress on performance of creative industry SMEs through creativity of SMEs owners as mediator variable, with total effects of 0.219 or 21.9%.