In this work, fibrin was used as a substrate to graft 2-hydroxyethyl methacrylate (HEMA) by free radical polymerization using potassium persulfate and sodium metabisulfite as redox initiators. The extent of grafting the synthetic polymer on the biopolymer was studied under various experimental conditions, and the optimum factors for affording maximum grafting were standardized. The graft, fib-g-p[HEMA], was characterized by Fourier transform infrared, scanning electron microscopy, and X-ray diffraction studies. The graft exhibited a higher shelf life than native fibrin. The biocompatibility of the graft has been tested by in vivo studies and the results, in terms of collagen formation and wound size, proved its suitability for wound healing.

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Semi-interpenetrating polymer networks (IPNs) have been prepared from polyurethane anionomers and poly(vinyl chloride) using sequential polymerization technique. These IPNs were compression molded and obtained as tough films. The hydrogen bonding interaction, glass transition temperature, and thermal stabilities were discussed based on Fourier-transform infrared spectrophotometer, differential scanning calorimetry, and thermogravimetric analysis. Morphology of the IPNs was characterized by scanning electron microscope and it reveals the formation of compatible IPNs. Tensile strength and hardness increase with increasing NCO/OH ratio and ionic