Autophagy was defective in KBD chondrocytes, but it was higher than in OA. The insufficient autophagy may be associated with apoptosis and mitochondrial change in the pathogenesis of KBD and OA.

Danshen can prevent articular cartilage degeneration in OA through the defense against oxidative stress.

Polymorphism of CYP2C19 was significantly associated with plasma concentration ratios of clopidogrel to its inactive metabolite SR26334. Clopidogrel metabolism was regulated by CYP2C19. The *2 and *3 allele carriage were independently associated with the antiplatelet effect of chronic clopidogrel therapy.

No abstract