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Fluorescent resonance energy transfer (FRET) with naturally exceptional selectivity is a powerful technique and widely used in chemical and biomedical analysis. However, it is still challenging for conventional FRET to perform as a high sensitivity compact sensor. Here we propose a novel ‘FRET on Fiber’ concept, in which a partially reduced graphene oxide (prGO) film is deposited on a fiber-optic modal interferometer, acting as both the fluorescent quencher for the FRET and the sensitive cladding for optical phase measurement due to refractive index changes in biochemical detection. The target analytes induced fluorescence recovery with good selectivity and optical phase shift with high sensitivity are measured simultaneously. The functionalized prGO film coated on the fiber-optic interferometer shows high sensitivities for the detections of metal ion, dopamine and single-stranded DNA (ssDNA), with detection limits of 1.2 nM, 1.3 μM and 1 pM, respectively. Such a prGO based ‘FRET on fiber’ configuration, bridging the FRET and the fiber-optic sensing technology, may serve as a platform for the realization of series of integrated ‘FRET on Fiber’ sensors for on-line environmental, chemical, and biomedical detection, with excellent compactness, high sensitivity, good selectivity and fast response

Oxide films of BaTiO3 and MgO were deposited on SrTiO3 single crystal substrates by laser molecular beam epitaxy. Reflection high-energy electron diffraction was performed in situ to investigate the change of growth mode and the lattice relaxation. Due to the different mismatches between epitaxial oxide films and substrates, two kinds of strain relaxation behavior during the growth process can be observed. For the BaTiO3∕SrTiO3 system with the small mismatch of 2.18%, the coherent epitaxial growth can be maintained within the critical thickness. The experimental data were well in accord with the elastic strain theory in the small mismatch system. The coherent epitaxial growth is crucial to fabricate the functional oxide superlattice. However, strained island can form at the initial period to release strain energy in the case of MgO∕SrTiO3 system with the large mismatch of 7.8%. It provides a useful practical method to realize self-organized nanostructures by introducing the moderate strain at interface. Our systematic study on the interface strain of functional oxide heteroepitaxial growth could give an instructive method to realize different heterostructures, e.g., superlattice and nanostructures.