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Introduction. Combined antihypertensive therapy is indicated in 94% of patients with hypertension. Fixed combinations are preferable to use as they have a high profile of effectiveness, safety, more convenient to use and significantly increase the adherence. Objective. To evaluate the effectiveness of triple fixed combination of amlodipine/indapamide/perindopril for the control of blood pressure in patients who did not achieve the target blood pressure level in the previous combined therapy. Materials and methods. The study included 44 patients with hypertension of high and very high risk of cardiovascular complications (mean age - 58.59±10.57 years, 17 men, 27 women). Blood pressure levels, quality of life, anxiety and depression levels, adherence, biochemical indices, levels of inflammation markers (CRP, IL-6, IL-10) and endothelial dysfunction (sVCAM-1, VEGF) were assessed in all patients at baseline and after 6 months of amlodipine/indapamide/perindopril therapy. Results. Against the backdrop of the treatment, all patients reached the target level of blood pressure (BP), pulse BP decreased by 30.3 mm Hg. (p

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Objective: To assess IL-6, IL-10 activity in hypertensive men with moderate or high cardiovascular risk (CVR). Design and method: 60 hypertensive men with moderate and high CVR were included. Two groups were formed: 1st - 30 hypertensive men with moderate CVR; 2nd - 30 men with high CVR. Control group - 15 men, 45–62 years old, without chronic diseases and hypertension. Anamnesis collection, CVR study, general examination, biochemical blood test, ECG, ECHO were held. IL-6, IL-10 were determined by the enzyme-linked immunosorbent assay method. The Mann-Whitney nonparametric test was used for groups comparison. The statistical significance of different values was determined by using the Pearson's Chi-square test. Correlation analysis was carried out on the basis of Spearman's nonparametric rank correlation. Results: IL-10 activity: moderate risk group - 5.18 [3.74; 7.03] pg/ml, high-risk group - 4.92 [2.96; 6.36] pg/ml, control group - 6.63 [5.90; 9.07] pg/ml. There was a statistically significant IL-10 decrease in the high-risk group in comparison with the control group (p = 0.0175). IL-6 activity: moderate risk group - 1.55 [0.75; 2.68] pg/ml, high-risk group - 1.16 [0.48; 2.41] pg/ml, control group - 1.02 [0.00; 9.83] pg/ml, there were no statistically significant differences in the groups. Correlation analysis revealed a multidirectional relationship between IL-10 and the hypertension duration in two groups: with a high risk a negative correlation was revealed (R = - 0.5, p < 0.01), with a moderate risk a positive correlation was revealed (R = 0.46, p < 0.05). IL-6 positively correlated with the thickness of the carotid artery intima-media complex (R = 0.41, p < 0.05) in men with moderate CVR. Conclusions: IL-10 decrease was revealed in hypertensive men with high CVR as compared to the healthy people. It can be used as an additional criterion for high CVR. The negative IL-10 correlation with the hypertension duration reflects the unfavorable development of hypertension in hypertensive men with high CVR. The detection of high IL-6 values in hypertensive men indicates the risk of endothelial dysfunction.